9-[(4-(2-Hydroxyethoxy)phenyl)sulfonyl]-6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole hydrochloride | 321523-81-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: 9-[(4-(2-Hydroxyethoxy)phenyl)sulfonyl]-6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole hydrochloride
• 英文别名: 2-[4-[(6-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]indol-9-yl)sulfonyl]phenoxy]ethanol;hydrochloride
• CAS: 321523-81-3
• 化学式: C₂₁H₂₄N₂O₄S*ClH
• 分子量: 436.96
• InChiKey: DRZXDGPRVRFIGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.49
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  88.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-[4-[(4-fluorophenyl)sulfonyl]phenyl]hydrazine 生成 9-[(4-(2-Hydroxyethoxy)phenyl)sulfonyl]-6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole hydrochloride
  参考文献：
  名称：

  1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

  摘要：

  本发明涉及替代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（X）和未取代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（XI），例如示例131中的化合物，可用于治疗抑郁症、肥胖症和其他中枢神经系统疾病。

  公开号：

  US20020111483A1

文献信息

• [EN] 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-B]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION<br/>[FR] 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-B]INDOLES PORTANT DES ARYLSULFONES EN POSITION 9
  申请人：UPJOHN CO

  公开号：WO2004096809A1

  公开（公告）日：2004-11-11

  The present invention discloses radioligands of 9-arylsulfone of the formula (I), or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

  本发明揭示了9-芳基砜的放射配体的化学式(I)，或其药用可接受的盐或对映体，它们在诊断抑郁症、肥胖和其他中枢神经系统疾病方面很有用。
• 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1196417A1

  公开（公告）日：2002-04-17
• [EN] 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION<br/>[FR] 1,2,3,4,5,6-HEXAHYDROAZEPINE[4,5-b]INDOLES CONTENANT DES ARYLSULFONES A LA POSITION 9
  申请人：UPJOHN CO

  公开号：WO2001005793A1

  公开（公告）日：2001-01-25

  The present invention is substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compounds of EXAMPLE (13), which are useful in treating depression, obesity and other CNS disorders.
• 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
  申请人：Pharmacia & Upjohn Company

  公开号：US20020111483A1

  公开（公告）日：2002-08-15

  The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compound of EXAMPLE 13 1 which are useful in treating depression, obesity and other CNS disorders.

  本发明涉及替代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（X）和未取代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（XI），例如示例131中的化合物，可用于治疗抑郁症、肥胖症和其他中枢神经系统疾病。