2-(1-((5-chloropyridin-2-yl)methyl)-6-fluoro-5-methoxy-2-methyl-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide | 1383924-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: 2-(1-((5-chloropyridin-2-yl)methyl)-6-fluoro-5-methoxy-2-methyl-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide
• 英文别名: 2-[1-[(5-chloropyridin-2-yl)methyl]-6-fluoro-5-methoxy-2-methylindol-3-yl]-N-(2-methoxypyridin-4-yl)-2-oxoacetamide
• CAS: 1383924-01-3
• 化学式: C₂₄H₂₀ClFN₄O₄
• 分子量: 482.899
• InChiKey: AJAXKMQNWUCVJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] FAAH INHIBITORS<br/>[FR] INHIBITEURS DE FAAH
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2012088469A1

  公开（公告）日：2012-06-28

  The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

  本公开涉及作为脂肪酰胺水解酶（FAAH）抑制剂有用的化合物。该公开还提供包括本公开化合物的药学上可接受的组合物，以及使用这些组合物在治疗或预防各种疾病中的方法。发明的化合物在表1中描述。
• FAAH Inhibitors
  申请人：Hudson Colleen

  公开号：US20150175599A1

  公开（公告）日：2015-06-25

  The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

  本公开涉及一种作为脂肪酸酰胺水解酶（FAAH）抑制剂有用的化合物。本公开还提供了包含本公开化合物的药学上可接受的组合物，以及使用这些组合物在治疗或预防各种疾病的方法。发明的化合物在表1中描述。
• FAAH INHIBITORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：EP2655356A1

  公开（公告）日：2013-10-30
• US9657012B2
  申请人：——

  公开号：US9657012B2

  公开（公告）日：2017-05-23
• [EN] USE OF FAAH INHIBITORS AS NEUROPROTECTIVE AGENTS IN THE CNS<br/>[FR] UTILISATION DES INHIBITEURS DE FAAH COMME AGENTS NEUROPROTECTEURS DU SNC
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2014004676A1

  公开（公告）日：2014-01-03

  The present disclosure relates to methods of using a fatty acid amide hydrolase (FAAH) inhibitor of Formula I alone or in combination with one or more additional therapeutic agents for the treatment or prevention of neuronal injury or neurodegeneration in a patient in need thereof.