1-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-ethylamine | 101783-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 1-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-ethylamine
• 英文别名: 1-(4,5-Dihydro-1H-imidazol-2-yl)-1-methyl-aethylamin；2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-amine
• CAS: 101783-74-8
• 化学式: C₆H₁₃N₃
• mdl: MFCD19208061
• 分子量: 127.189
• InChiKey: WOCSROBZETXEHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-[1-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-ethyl]-toluene-4-sulfonamide 在 氨 、 sodium 作用下， 生成 1-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-ethylamine
  参考文献：
  名称：

  Mengelberg, Chemische Berichte, 1958, vol. 91, p. 1961,1964

  摘要：

  DOI：

文献信息

• [EN] LYSINE COMPOUNDS AND THEIR USE IN SITE- AND CHEMOSELECTIVE MODIFICATION OF PEPTIDES AND PROTEINS<br/>[FR] COMPOSÉS LYSINES ET LEUR UTILISATION DANS UNE MODIFICATION SÉLECTIVE DE SITE ET CHIMIOSÉLECTIVE DE PEPTIDES ET PROTÉINES
  申请人：STICHTING HET NL KANKER I

  公开号：WO2010131962A2

  公开（公告）日：2010-11-18

  The present invention concerns new thiolysine and selenolysine compounds that can be used as building blocks for peptides and proteins, providing ligation handles for site-and chemoselective modification of said peptides and proteins. In particular, the invention provides. In particular, the invention provides (the use of) the compounds 5-thiolysine (also referred to as δ-thiolysine); 4-thiolysine (also referred to as γ-thiolysine); 5-selenolysine (also referred to as δ-selenolysine) and 4- selenolysine (also referred to as γ-selenolysine). The positioning of the thiol or selenol group at the respective carbon atom allows for a very efficient intramolecular transfer reaction to take place after conjugation with a selected ligand, and the thiol or selenol group may subsequently be removed using reported procedures, thereby restoring the native lysine structure, or be used as an additional conjugation handle. The methodology is fast and gives well-defined material.
• [EN] METHOD FOR PREPARING GRAFT COPOLYMER<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COPOLYMÈRE GREFFÉ<br/>[KO] 그라프트 공중합체의 제조방법
  申请人：LG CHEMICAL LTD

  公开号：WO2021015526A1

  公开（公告）日：2021-01-28

  본 발명은 20 ℃에서 물에 대한 용해도가 10 g/100 g 이상이고 물에서 10 시간 반감기 분해온도가 80 ℃이하인 아조계 개시제의 존재 하에, 디엔계 고무질 중합체에 방향족 비닐계 단량체, 시안화 비닐계 단량체를 그라프트 유화 중합하는 단계를 포함하고, 상기 그라프트 유화 중합을 45 내지 55 ℃에서 개시하는 그라프트 공중합체의 제조방법에 관한 것으로서, 본 발명을 따르면 저온에서 중합을 수행할 수 있으면서, 중합안정성이 우수한 그라프트 공중합체의 제조방법을 제공할 수 있다.