| 887326-78-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• CAS: 887326-78-5
• 化学式: C₄₇H₇₅NO₁₆Si₂
• 分子量: 966.281
• InChiKey: JYTHBRINYNPHHO-LGZIIRHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.36
• 重原子数：
  66.0
• 可旋转键数：
  19.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  227.23
• 氢给体数：
  5.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 以78%的产率得到[(2S,3R,4S,5R,6S)-6-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-[4-[(2R)-3-methoxy-3-oxo-2-(phenylmethoxycarbonylamino)propyl]phenoxy]oxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl] 3-methylbutanoate
  参考文献：
  名称：

  Synthetic Studies toward Mannopeptimycin-E:  Synthesis of the O-Linked Tyrosine 1,4-α,α-manno,manno-Pyranosyl Pyranoside

  摘要：

  The enantioselective synthesis of the C-4' acylated 1,4-alpha,alpha-manno,manno-disaccharide fragment of mannopeptimycin-E has been achieved in seven steps from D-tyrosine. The route relies upon diastereoselective palladium-catalyzed glycosylation, diastereoselective reduction, and diastereoselective bis-dihydroxylation. The efficiency of the synthesis is demonstrated by the high overall yield (37%) and the preparation of various analogues.

  DOI：

  10.1021/ol060254a
• 作为产物：
  描述：

  (R)-2-Benzyloxycarbonylamino-3-(4-{(2S,5R,6S)-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-[(2R,5R,6S)-6-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-5,6-dihydro-2H-pyran-2-yloxy]-5,6-dihydro-2H-pyran-2-yloxy}-phenyl)-propionic acid methyl ester 在 四氧化锇 、 N-甲基吲哚酮 、 N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Synthetic Studies toward Mannopeptimycin-E:  Synthesis of the O-Linked Tyrosine 1,4-α,α-manno,manno-Pyranosyl Pyranoside

  摘要：

  The enantioselective synthesis of the C-4' acylated 1,4-alpha,alpha-manno,manno-disaccharide fragment of mannopeptimycin-E has been achieved in seven steps from D-tyrosine. The route relies upon diastereoselective palladium-catalyzed glycosylation, diastereoselective reduction, and diastereoselective bis-dihydroxylation. The efficiency of the synthesis is demonstrated by the high overall yield (37%) and the preparation of various analogues.

  DOI：

  10.1021/ol060254a