2-Ethylamino-Δ¹-pyrrolin | 872-83-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 2-Ethylamino-Δ¹-pyrrolin
• 英文别名: N-ethyl-3,4-dihydro-2H-pyrrol-5-amine
• CAS: 872-83-3
• 化学式: C₆H₁₂N₂
• mdl: MFCD19159887
• 分子量: 112.175
• InChiKey: XHZVBQOIVAXSRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA
  申请人：Zhu Bing-Yan

  公开号：US20120083602A1

  公开（公告）日：2012-04-05

  Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

  本发明涉及一种新型苯甲酰胺类化合物，包括其药学上可接受的异构体、盐、水合物、溶剂化合物和前药衍生物，具有对哺乳动物因子Xa的活性。本发明还涉及含有这种化合物的组合物。这些化合物和组合物在体内或体外用于预防或治疗凝血障碍。
• ALPHA ADRENERGIC RECEPTOR MODULATORS
  申请人：Chow Ken

  公开号：US20120208821A1

  公开（公告）日：2012-08-16

  Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

  本文描述了一种通过调节一个或多个α肾上腺素受体治疗疾病和病况的有用化合物。这些化合物可以包括萘、喹啉、苯并咪唑或异喹啉作为核心结构。描述了制备、使用和配制这些化合物的方法。
• Alpha adrenergic receptor modulators
  申请人：Chow Ken

  公开号：US20120238615A1

  公开（公告）日：2012-09-20

  Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor, in particular the alpha 2C receptor. The compounds can include N-(2,3-substituted phenyl)-3,4-dihydro-2H-pyrrol-5-amine derivatives. Methods of making, using and formulating these compounds are described
• US7312235B2
  申请人：——

  公开号：US7312235B2

  公开（公告）日：2007-12-25
• US8063036B2
  申请人：——

  公开号：US8063036B2

  公开（公告）日：2011-11-22