[4-(Phosphonooxy)phenyl]acetic acid | 175296-90-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [4-(Phosphonooxy)phenyl]acetic acid
• 英文别名: 2-(4-phosphonooxyphenyl)acetic acid
• CAS: 175296-90-9
• 化学式: C₈H₉O₆P
• 分子量: 232.13
• InChiKey: YVWMYFBCZXSSIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PRODRUGS OF 2-(4-(3-((4-AMINO-7-CYANO-IMIDAZO[2,1-F][1,2,4]TRIAZIN-2-YL)AMINO)PHENYL)PIPERAZ IN-1-YL)PROPANAMIDE DERIVATIVES AS CK2 INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] PROMÉDICAMENTS DE DÉRIVÉS 2-(4-(3-((4-AMINO-7-CYANO-IMIDAZO[2,1-F][1,2,4]TRIAZIN-2-YL)AMINO)PHÉNYL)PIPÉRAZIN-1-YL)PROPANAMIDE UTILISÉS COMME INHIBITEURS DE CK2 POUR LE TRAITEMENT DU CANCER
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017070135A1

  公开（公告）日：2017-04-27

  PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The formula (I) 2-(aminophenylamino)-4- amino-7-cyano-imidazo[2,1-f][1,2,4]triazine derivatives inhibit CK2 protein kinase activity, thereby making them useful for treating cancer, psoriasis and rheumatoid arthritis.

  PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS 该发明提供了公式(I)及其前药的药用活性化合物。公式(I)2-(氨基苯胺)-4-氨基-7-氰基咪唑[2,1-f][1,2,4]三嗪衍生物抑制CK2蛋白激酶活性，因此可用于治疗癌症、牛皮癣和类风湿性关节炎。
• [EN] HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME<br/>[FR] COMPOSÉS HÉTÉROARYLE UTILES EN TANT QU'INHIBITEURS DE L'ENZYME D'ACTIVATION SUMO
  申请人：DUFFEY MATTHEW O

  公开号：WO2016004136A1

  公开（公告）日：2016-01-07

  Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

  公开了公式(I)的化合物或其药物可接受的盐； 其中Y、Ra、Ra'、Rb、Rc、X1、X2、X3、Rd、Z1和Z2具有本文所述的值，并且星号位置表示的立体化学配置指示绝对立体化学。 根据本公开的化学实体可用作Sumo激活酶（SAE）的抑制剂。 进一步提供了包含本公开化合物的药物组合物以及使用该组合物治疗增殖性、炎症性、心血管和神经退行性疾病或病症的方法。
• BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF
  申请人：Bristol-Myers Squibb Company

  公开号：US20140087992A1

  公开（公告）日：2014-03-27

  Disclosed are compounds of Formula (I) and/or salts thereof: wherein R 1 is —CH 2 CH 2 CF 3 ; R 2 is —CH 2 CH 2 CF 3 or —CH 2 CH 2 CH 2 CF 3 ; R 3 is H, —CH 3 , or R x ; R 4 is H or R y ; Ring A is phenyl or pyridinyl; and R x , R y , R a , R b , y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.

  公开了公式(I)的化合物及/或其盐：其中R1为-CH2CH2CF3；R2为-CH2CH2CF3或-CH2CH2CH2CF3；R3为H，-CH3或Rx；R4为H或Ry；环A为苯基或吡啶基；Rx，Ry，Ra，Rb，y和z在此定义。还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓多种治疗领域，如癌症的疾病或病症进展方面非常有用，或者作为这些化合物的前药。
• [EN] CRYSTALLINE FORMS OF ((((4-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)AMINO)-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL)CARBONYL)(PROPYL)CARBAMOYL)OXY)METHYL (4-(PHOSPHONOOXY)PHENYL)ACETATE, PREPARATION AND USE THEREOF<br/>[FR] FORMES CRISTALLINES DE ((((4-((5-(CYCLOPROPYLCARBAMOYL)-2-MÉTHYLPHÉNYL)- AMINO)-5-MÉTHYLPYRROLO-[2,1-F][1,2,4]TRIAZIN-6-YL)CARBONYL)(PROPYL)-
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009158450A1

  公开（公告）日：2009-12-30

  The present invention generally relates to crystalline forms of ((((4-((5- (cyclopropylcart>amoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2, 1 -J][ I,2,4]triazin- 6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate. The present invention also generally relates to a pharmaceutical composition comprising said crystalline form, as well of methods of obtaining and using the crystalline form for the treatment of inflammatory-associated diseases.

  本发明一般涉及晶体形式的((((4-((5-(环丙基卡托酰)-2-甲基苯基)氨基)-5-甲基吡咯[2,1-j][1,2,4]三嗪-6-基)羰基)(丙基)羰基)氧)甲基(4-(磷酸氧)苯基)乙酸酯。本发明还一般涉及包括所述晶体形式的药物组合物，以及获得和使用该晶体形式用于治疗炎症相关疾病的方法。
• [EN] ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS<br/>[FR] COMPOSÉS ALKYL, FLUOROALKYL-1,4-BENZODIAZÉPINONES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047374A1

  公开（公告）日：2014-03-27

  Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3; R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3; R3 is H, CH3, or Rx; R4 is H or Ry; and Rx, Ry, Ra, Rb, Rc, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. The compounds of Formula (I) also include prodrugs of the Notch inhibitor compounds.

  公开的是Formula (I)的化合物和/或其盐：其中：R1为CH2CH2CF3；R2为CH2（环丙基）、CH（CH3）（环丙基）或CH2CH2CH3；R3为H、CH3或Rx；R4为H或Ry；Rx、Ry、Ra、Rb、Rc、y和z在此定义。还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓多种治疗领域的疾病或疾病的进展方面非常有用，如癌症。Formula (I)的化合物还包括Notch抑制剂化合物的前药。