chaetomugilin R | 1319729-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂非酮类
• 英文名称: chaetomugilin R
• 英文别名: (7R,8S,8aS)-5-chloro-7,8-dihydroxy-3-[(E,3S,4S)-4-hydroxy-3-methylpent-1-enyl]-7-methyl-8,8a-dihydro-1H-isochromen-6-one
• CAS: 1319729-87-7
• 化学式: C₁₆H₂₁ClO₅
• 分子量: 328.793
• InChiKey: HYQLBUHERBRGKE-HKOMCDGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  chaetomugilin R 在 potassium hydroxide 、 硫酸 作用下， 以 水 为溶剂， 反应 3.0h， 以0.6 mg的产率得到(2E,4S,5S)-5-hydroxy-4-methylhex-2-enoic acid
  参考文献：
  名称：

  New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities

  摘要：

  Four new metabolites, chaetomugilins P-R and 11-epi-chaetomugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereo-structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetomugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.05.008

文献信息

• New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities
  作者：Takeshi Yamada、Yasuhide Muroga、Masaaki Jinno、Tetsuya Kajimoto、Yoshihide Usami、Atsushi Numata、Reiko Tanaka

  DOI：10.1016/j.bmc.2011.05.008

  日期：2011.7

  Four new metabolites, chaetomugilins P-R and 11-epi-chaetomugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereo-structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetomugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. (C) 2011 Elsevier Ltd. All rights reserved.