8-[2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-3-yl]-N-hydroxy-8-oxooctanamide | 1236199-64-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 8-[2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-3-yl]-N-hydroxy-8-oxooctanamide
• 英文别名: 8-[2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-3-yl]-N-hydroxy-8-oxooctanamide
• CAS: 1236199-64-6
• 化学式: C₁₅H₂₈Cl₂N₃O₅P
• 分子量: 432.284
• InChiKey: ZKWNQXNAJPZDKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  99.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Hydroxamic Acid Derivatives
  申请人：Chen Yu

  公开号：US20110269706A1

  公开（公告）日：2011-11-03

  The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.
• HYDROXAMIC ACID DERIVATIVES
  申请人：Purdue Pharmaceutical Products L.P.

  公开号：US20140066419A1

  公开（公告）日：2014-03-06

  The present invention is directed to a method of alleviating, relieving, altering, remedying, ameliorating, improving or affecting a neoplastic disease or an immune disease, the method comprising administering to a subject in need thereof an effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein P, Z, and m are defined herein above.
• US9096627B2
  申请人：——

  公开号：US9096627B2

  公开（公告）日：2015-08-04
• USRE46144E1
  申请人：——

  公开号：USRE46144E1

  公开（公告）日：2016-09-13
• [EN] HYDROXAMIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS D'ACIDE HYDROXAMIQUE
  申请人：CRYSTAL BIOPHARMACEUTICAL LLC

  公开号：WO2010085377A2

  公开（公告）日：2010-07-29

  The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.