Tris(salicylaldehyd)-phosphat | 37829-98-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Tris(salicylaldehyd)-phosphat
• 英文别名: Tris(formylphenyl)phosphate；tris(2-formylphenyl) phosphate
• CAS: 37829-98-4
• 化学式: C₂₁H₁₅O₇P
• 分子量: 410.32
• InChiKey: KXOFLPNGBJMWNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE
  申请人：Gao Zhiqiang

  公开号：US20100194409A1

  公开（公告）日：2010-08-05

  The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.
• METHOD OF ELECTRICALLY DETECTING A NUCLEIC ACID MOLECULE
  申请人：Kong Jinming

  公开号：US20100285601A1

  公开（公告）日：2010-11-11

  The method is performed by means of a pair of electrodes that are arranged at a distance and within a sensing zone. A nucleic acid capture molecule with an uncharged backbone and a nucleotide sequence that is at least partially complementary to at least a portion of a strand of the target nucleic acid molecule, is immobilised on an immobilisation unit. The immobilisation unit, which is arranged within the sensing zone, is contacted with a solution suspected to comprise the target nucleic acid molecule, which hybridizes to the nucleic acid capture molecule. An activation agent is added, which has an electrostatic net charge complementary to the net charge of the target nucleic acid molecule. It associates to the complex of nucleic acid capture molecule and target nucleic acid molecule. Added is a water soluble polymer with at least one polymer strand and with an electrostatic net charge that is complementary to the net charge of the activation agent. Thus the polymer associates to the activation agent. A metal salt is added, which can act as an oxidant and the metal ions of which have an electrostatic net charge complementary to the net charge of the polymer. The metal ions associate to the polymer. Upon adding a reducing agent, the latter reduces the metal ions, forming a metal wire. The presence of the analyte molecule is determined based on an electrical characteristic of a region in the sensing zone that is affected by the metal wire.
• [EN] METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE<br/>[FR] PROCÉDÉ DE DÉTECTION ÉLECTRIQUE D'UNE MOLÉCULE D'ANALYTE BIOLOGIQUE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2008020813A1

  公开（公告）日：2008-02-21

  [EN] The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.
  [FR] L'invention concerne un procédé de détection électrique d'une molécule d'analyte biologique au moyen d'une paire d'électrodes. Les électrodes sont disposées à distance l'une de l'autre à l'intérieur d'une zone de détection. Une molécule de capture, ayant une affinité avec la molécule d'analyte et étant capable de former un complexe avec la molécule d'analyte, est immobilisée sur une unité d'immobilisation. L'unité d'immobilisation est mise en contact avec une solution comprenant la molécule d'analyte. La molécule d'analyte est autorisée à former un complexe avec la molécule de capture. L'invention concerne également une sonde définie par un marqueur nanoparticulaire comprenant ou consistant en une matière conductrice de l'électricité capable d'interagir chimiquement avec la molécule d'analyte. Dans le procédé de l'invention, un marqueur nanoparticulaire conducteur de l'électricité est ajouté. Ainsi, le marqueur nanoparticulaire conducteur de l'électricité est autorisé à s'associer au complexe formé entre la molécule de capture et la molécule d'analyte. La présence de la molécule d'analyte est déterminée sur la base d'une caractéristique électrique, influencée par le marqueur nanoparticulaire conducteur de l'électricité, d'une région dans la zone de détection.
• [EN] METHOD OF ELECTRICALLY DETECTING A NUCLEIC ACID MOLECULE<br/>[FR] PROCÉDÉ DE DÉTECTION ÉLECTRIQUE D'UNE MOLÉCULE D'ACIDE NUCLÉIQUE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2009041917A1

  公开（公告）日：2009-04-02

  The method is performed by means of a pair of electrodes that are arranged at a distance and within a sensing zone. A nucleic acid capture molecule with an uncharged backbone and a nucleotide sequence that is at least partially complementary to at least a portion of a strand of the target nucleic acid molecule, is immobilised on an immobilisation unit. The immobilisation unit, which is arranged within the sensing zone, is contacted with a solution suspected to comprise the target nucleic acid molecule, which hybridiszes to the nucleic acid capture molecule. An activation agent is added, which has an electrostatic net charge complementary to the net charge of the target nucleic acid molecule. It associates to the complex of nucleic acid capture molecule and target nucleic acid molecule. Added is a water soluble polymer with at least one polymer strand and with an electrostatic net charge that is complementary to the net charge of the activation agent. Thus the polymer associates to the activation agent. A metal salt is added, which can act as an oxidant and the metal ions of which have an electrostatic net charge complementary to the net charge of the polymer. The metal ions associate to the polymer. Upon adding a reducing agent, the latter reduces the metal ions, forming a metal wire. The presence of the analyte molecule is determined based on an electrical characteristic of a region in the sensing zone that is affected by the metal wire.