| 91709-75-0

• 分子结构分类: 有机化合物 - 有机盐 - 有机硫酸盐
• CAS: 91709-75-0
• 化学式: C₆H₁₈N₄*Cu*O₄S
• 分子量: 305.845
• InChiKey: BVBSKOOVWMFDSP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  copper(ll) sulfate pentahydrate 、 三乙烯四胺 以 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines

  摘要：

  Copper is an essential trace element involved in many physiological processes. Since disorder of copper homeostasis is observed in various pathologies, copper chelators may represent a promising therapeutic tool. This study was aimed at: 1) formation of an in vitro methodology for screening of copper chelators, and 2) detailed analysis of the interaction of copper with clinically used D-penicillamine (D-PEN), triethylenetetramine (trientine), experimentally tested 8-hydroxyquinolines, and the disodium salt of EDTA as a standard chelator. Methodology based on bathocuproinedisulfonic add disodium salt (BCS), usable at (patho)physiologically relevant pHs (4.5-7.5), enabled assessment of both cuprous and cupric ions chelation and comparison of the relative affinities of the tested compounds for copper. In the case of potent chelators, the stoichiometry could be estimated too. Clioquinol, chloroxine and EDTA formed very stable complexes with Cu+/Cu2+ at all tested pHs, while copper complexes with trientine were stable only under neutral or slightly acidic conditions. Non-substituted 8-hydroxyquinoline was a less efficient copper chelator, but still unequivocally more potent than D-PEN. Both 8-hydroxyquinoline and D-PEN chelation potencies, similarly to that of trientine, were pH-dependent and decreased with pH. Moreover, only D-PEN was able to reduce cupric ions. Conclusively, BCS assay represents a rapid, simple and precise method for copper chelation measurement. In addition, lower binding affinity of D-PEN compared with 8-hydroxyquinolines and trientine was demonstrated. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.02.011

文献信息

• SYNTHESIS OF SAPO-18 AND THE CATALYTIC APPLICATIONS THEREOF
  申请人：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

  公开号：US20170259253A1

  公开（公告）日：2017-09-14

  Synthesis of the silicoaluminophosphate and metal silicoaluminophosphate polymorphs of the molecular sieve SAPO-18 using cyclic quaternary ammoniums as organic structure-directing agents (OSDA) and use thereof as a catalyst.

  使用环状季铵作为有机结构指导剂（OSDA），合成SAPO-18分子筛的硅铝磷酸盐和金属硅铝磷酸盐多晶体形态，并将其用作催化剂。