3,3-Dimethyl-butyl-phosphat | 16791-51-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 3,3-Dimethyl-butyl-phosphat
• 英文别名: 3,3-Dimethylbutyl Dihydrogen Phosphate
• CAS: 16791-51-8
• 化学式: C₆H₁₅O₄P
• 分子量: 182.156
• InChiKey: OGEDDHTVRJGQJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Phosphoric acid 3,3-dimethyl-butyl ester 2-hydroxy-phenyl ester 在 碘苯二乙酸 、 水 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以70%的产率得到3,3-Dimethyl-butyl-phosphat
  参考文献：
  名称：

  Oxidative Cleavage ofo-Hydroxyphenyl Phosphate by Iodobenzene Diacetate

  摘要：

  AbstractThe protecting o‐hydroxyphenyl group in the synthesis of mono‐ or dialkyl phosphates (6 or 8) could be removed by oxidative cleavage of mono‐ or dialkyl o‐hydroxyphenyl phosphates (3 or 7) using iodobenzene diacetate.

  DOI：

  10.1002/jccs.199900133

文献信息

• Tagged nucleotides useful for nanopore detection
  申请人：Roche Sequencing Solutions, Inc.

  公开号：US10669580B2

  公开（公告）日：2020-06-02

  The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.

  本公开涉及包含负电荷聚合物分子的化合物，该负电荷聚合物分子能够进入纳米孔，并且在正离子存在的情况下进入纳米孔后会增加正离子通过纳米孔的流量。本公开提供了制备这些化合物的方法以及将其用作纳米孔可检测标签的方法，特别是用于基于纳米孔的核酸检测和测序。
• TAGGED NUCLEOTIDES USEFUL FOR NANOPORE DETECTION
  申请人：Roche Sequencing Solutions, Inc.

  公开号：US20180057870A1

  公开（公告）日：2018-03-01

  The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.
• [EN] CARBIDOPA AND L-DOPA PRODRUGS AND METHODS OF USE<br/>[FR] PROMÉDICAMENTS DE CARBIDOPA ET DE L-DOPA ET MÉTHODES D'UTILISATION
  申请人：ABBVIE INC

  公开号：WO2017184871A1

  公开（公告）日：2017-10-26

  The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.