3-Benzoyl-9-(2-propynyloxy)-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole | 389115-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: 3-Benzoyl-9-(2-propynyloxy)-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole
• 英文别名: phenyl-(9-prop-2-ynoxy-2,4,5,6-tetrahydro-1H-azepino[4,5-b]indol-3-yl)methanone
• CAS: 389115-62-2
• 化学式: C₂₂H₂₀N₂O₂
• 分子量: 344.413
• InChiKey: RDHSXVSBPRMSDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  45.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Azepino[4,5-b]pyrano[3,2-e]indoles
  申请人：——

  公开号：US20020022616A1

  公开（公告）日：2002-02-21

  1 wherein: R 1 -R 5 , m, n, p, and the bonds a and b represented by - - - have any of the values, specific values, or preferred values described in the specification; or a salt or solvate thereof. The invention also provides pharmaceutical compositions comprising such a compound, as well as intermediates and processes useful for preparing such a compound, and therapeutic methods including the administration of such a compound.

  本发明提供一种化合物，其中R1-R5，m，n，p和由- - -表示的键a和b具有规范中描述的任何值、具体值或优选值；或其盐或溶剂化物。本发明还提供包含这种化合物的药物组成物，以及用于制备这种化合物的中间体和方法，以及包括给予这种化合物的治疗方法。
• AZEPINO 4,5-B]PYRANO 3,2-E]INDOLES
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1296988A1

  公开（公告）日：2003-04-02
• US6503899B2
  申请人：——

  公开号：US6503899B2

  公开（公告）日：2003-01-07
• [EN] SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES<br/>[FR] 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-B]PYRANO[3,2-E]INDOLES SUBSTITUTES
  申请人：UPJOHN CO

  公开号：WO2002004456A1

  公开（公告）日：2002-01-17

  Disclosed are compounds of general structural formula (I), and use of the compounds, salts and solvates thereof, and pharmaceutical compositions containing the same in the treatment of a diesase, disorder, and/or condition in a mammal wherein a 5-HT receptor is implicated and modulation of a 5-HT function is desired.
• [EN] AZEPINO[4,5-B]PYRANO[3,2-E]INDOLES<br/>[FR] AZÉPINO[4,5-B]PYRANO[3,2-E]INDOLES
  申请人：UPJOHN CO

  公开号：WO2002004457A1

  公开（公告）日：2002-01-17

  The invetion provides a compound of formula (1), wherein: R1-R5, m, m, p, and the bonds a and b represented by --- have any of the values, specific values, or preferred values described in the specification; or a salt or solvate thereof. The invention also provides pharmaceutical compositions comprising such a compound, as well as intermediates and processes useful for preparing such a compound, and therapeutic methods including the administration of such a compound.