N-{5-acetyl-4,6-dihydropyrrolo[3,4-c]pyrazol-3-yl}-thiophene-2-carboxamide | 398496-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡唑类
• 英文名称: N-{5-acetyl-4,6-dihydropyrrolo[3,4-c]pyrazol-3-yl}-thiophene-2-carboxamide
• 英文别名: N-(5-acetyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl)thiophene-2-carboxamide
• CAS: 398496-02-1
• 化学式: C₁₂H₁₂N₄O₂S
• 分子量: 276.319
• InChiKey: YSLPXWINPFIBJP-UHFFFAOYSA-N

物化性质

• 沸点：
  470.5±45.0 °C(Predicted)
• 密度：
  1.528±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
  申请人：——

  公开号：US20030171357A1

  公开（公告）日：2003-09-11

  Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.

  Bicyclo-pyrazole化合物的化学式（I），如本文所定义，可用于治疗与失调蛋白激酶相关的疾病。
• Bicyclo-Pyrazoles and Pharmaceutical Compositions Comprising Them
  申请人：Fancelli Daniele

  公开号：US20090221632A1

  公开（公告）日：2009-09-03

  Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.

  公式（I）所定义的双环吡唑化合物可用于治疗与失调的蛋白激酶相关的疾病。
• BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pfizer Italia S.r.l.

  公开号：EP1320531B1

  公开（公告）日：2010-09-08
• Compositions Useful As Inhibitors of Protein Kinases
  申请人：Binch Hayley

  公开号：US20100087467A1

  公开（公告）日：2010-04-08

  The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R 1 , and R 2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.
• US7531531B2
  申请人：——

  公开号：US7531531B2

  公开（公告）日：2009-05-12