1-(5-{5-chloro-2-[1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol | 1350378-00-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: 1-(5-{5-chloro-2-[1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol
• 英文别名: 1-[5-[5-chloro-2-[1-(pyridin-3-ylmethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl]cyclobutan-1-ol
• CAS: 1350378-00-5
• 化学式: C₂₃H₁₉ClN₆OS
• 分子量: 462.962
• InChiKey: ZPNNOIBJNPSHPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES
  申请人：Michaelides Michael R.

  公开号：US20110281842A1

  公开（公告）日：2011-11-17

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R 1 , R 2 , R 3 , R 4a , R 5 , and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.

  本发明涉及式(I)的化合物或药用可接受的盐，其中A、B、R1、R2、R3、R4a、R5和Z在描述中有定义。本发明还涉及制备所述化合物的方法，以及含有所述化合物的组合物，用于抑制aurora等激酶。
• [EN] PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES<br/>[FR] PYRROLOPYRIDINE ET PYRROLOPYRIMIDINE INHIBITRICES DE KINASES
  申请人：ABBOTT LAB

  公开号：WO2011143459A1

  公开（公告）日：2011-11-17

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.