4-硝基苯甲基(4S,5R,6S)-3-[(二苯基磷羧基)氧代]-6-[(R)-1-羟基乙基]-4-甲基-7-羰基-1-氮杂二环[3.2.0]庚-2-烯-2-羧酸酯 | 189188-38-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 4-硝基苯甲基(4S,5R,6S)-3-[(二苯基磷羧基)氧代]-6-[(R)-1-羟基乙基]-4-甲基-7-羰基-1-氮杂二环[3.2.0]庚-2-烯-2-羧酸酯
• 中文别名: 美罗培南杂质
• 英文名称: (4-Nitrophenyl)methyl (4S,5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• CAS: 189188-38-3
• 化学式: C₂₉H₂₇N₂O₁₀P
• 分子量: 594.515
• InChiKey: STULDTCHQXVRIX-NUQURWJTSA-N

物化性质

• 沸点：
  722.4±60.0 °C(Predicted)
• 密度：
  1.47±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4-硝基苯甲基(4S,5R,6S)-3-[(二苯基磷羧基)氧代]-6-[(R)-1-羟基乙基]-4-甲基-7-羰基-1-氮杂二环[3.2.0]庚-2-烯-2-羧酸酯 、 泰比培南酯中间体 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  一种替比培南酯的制备方法

  摘要：

  本发明涉及医药技术领域，具体地，本发明涉及一种替比培南酯的制备方法。本发明提供一种替比培南酯的制备方法，至少包括以下步骤：步骤1：缩合反应；步骤2：氢化反应；步骤3：酯化反应；步骤4：提纯、精制。

  公开号：

  CN108640920B

文献信息

• IMPROVED METHOD FOR THE CRYSTALLIZATION OF INTERMEDIATES OF CARBAPENEM ANTIBIOTICS
  申请人：Kaneka Corporation

  公开号：EP2014666A1

  公开（公告）日：2009-01-14

  The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound. According to the method, the crystal having a high quality and a high stability and excellent filterability at the time of recovering the crystal can be obtained.

  本发明涉及一种作为合成 1β-甲基碳青霉烯化合物的常用中间体极为有用的氮杂环丁酮化合物。本发明提供了一种结晶方法，以获得比传统晶体质量更高、稳定性更强、在回收晶体时过滤性极佳的晶体；杂质含量低的氮杂环丁酮化合物；以及晶体粒度分布可控、处理性和稳定性更好的氮杂环丁酮化合物。结晶的方法是向溶液中加入烃类溶剂，溶液中溶解有作为合成 1β-甲基碳青霉烯化合物的常用中间体非常有用的氮杂环丁酮化合物，并有籽晶存在，籽晶的重量为氮杂环丁酮化合物重量的 200% 或更少。根据该方法，可以得到高质量、高稳定性和在回收晶体时具有极佳过滤性的晶体。
• KUMAGAI, TOSIO;ABEH, TAKAO;MATIDA, RESUKEH;XAYASI, TAKAAKI;NAGASEH, YUNOS+
  作者：KUMAGAI, TOSIO、ABEH, TAKAO、MATIDA, RESUKEH、XAYASI, TAKAAKI、NAGASEH, YUNOS+

  DOI：——

  日期：——
• Crystallization Method for Intermediates of Carbapenem Antibiotics
  申请人：Nishino Keita

  公开号：US20090118496A1

  公开（公告）日：2009-05-07

  The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound. According to the method, the crystal having a high quality and a high stability and excellent filterability at the time of recovering the crystal can be obtained.
• US8093378B2
  申请人：——

  公开号：US8093378B2

  公开（公告）日：2012-01-10