N-Methyl-2-phenyl-1,4-thiazane | 88789-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: N-Methyl-2-phenyl-1,4-thiazane
• 英文别名: 4-Methyl-2-phenylthiomorpholine
• CAS: 88789-01-9
• 化学式: C₁₁H₁₅NS
• 分子量: 193.313
• InChiKey: XCDRTHCYVUOCQT-UHFFFAOYSA-N

物化性质

• 沸点：
  300.8±42.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Methyl-2-phenyl-1,4-thiazane 在 三氟过氧乙酸 作用下， 以 三氟乙酸 为溶剂， 反应 1.0h， 以85%的产率得到N-Methyl-2-phenyl-1,4-thiazane 1-Oxide
  参考文献：
  名称：

  Synthesis of 2-phenyl-, 3-phenyl-, cis-2,3-diphenyl-, and trans-2,3-diphenyl-1,4-thiazanes and derivatives (N-methyl, N-alkoxycarbonyl, S-oxides, and S,S-dioxides)

  摘要：

  DOI：

  10.1021/jo00041a029
• 作为产物：
  描述：

  2-Phenyl-3-oxo-1,4-thiazane 在 盐酸 、 sodium tetrahydroborate 、 溶剂黄146 作用下， 反应 33.5h， 生成 N-Methyl-2-phenyl-1,4-thiazane
  参考文献：
  名称：

  Synthesis of 2-phenyl-, 3-phenyl-, cis-2,3-diphenyl-, and trans-2,3-diphenyl-1,4-thiazanes and derivatives (N-methyl, N-alkoxycarbonyl, S-oxides, and S,S-dioxides)

  摘要：

  DOI：

  10.1021/jo00041a029

文献信息

• CINNAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1757591A1

  公开（公告）日：2007-02-28

  The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) -C≡C- or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.

  本发明涉及一种由式（I）表示的化合物： (其中Ar1代表可被1至3个取代基取代的咪唑基；Ar2代表可被1至3个取代基取代的吡啶基、嘧啶基或苯基；X1代表(1)-C≡C-或(2)可被取代的双键等；R1和R2代表例如可被取代的C1-6烷基或C3-8环烷基）或其药理学上可接受的盐，以及其作为药剂的用途。
• Process for preparing phenyl-, pyridinyl- or pyrimidinyl-substituted imidazoles
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2261218A2

  公开（公告）日：2010-12-15

  The present invention relates to a process for preparing a compound of formula (6a): which comprises the step of: subjecting a compound of formula (5a): and a compound of formula (4a): to a coupling reaction,

  本发明涉及一种制备式（6a）化合物的工艺： 其中包括以下步骤 将式（5a）化合物 和式 (4a) 的化合物： 进行偶联反应、
• Modulators of hepatocyte growth factor/c-Met activity
  申请人：Zembower E. David

  公开号：US20080058312A1

  公开（公告）日：2008-03-06

  This invention is directed to compounds and compositions that have biological properties useful for modulating HGF/SF activity. In certain embodiments, said compounds and compositions may be used in the treatment and prophylaxis of cancer or other dysproliferative diseases and inflammatory diseases such as rheumatoid arthritis.
• COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER
  申请人：ARGONAUT THERAPEUTICS LIMITED

  公开号：US20200325128A1

  公开（公告）日：2020-10-15

  The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of proliferative diseases, such as cancer.
• Synthesis of 2-phenyl-, 3-phenyl-, cis-2,3-diphenyl-, and trans-2,3-diphenyl-1,4-thiazanes and derivatives (N-methyl, N-alkoxycarbonyl, S-oxides, and S,S-dioxides)
  作者：J. L. Garcia Ruano、M. C. Martinez、J. H. Rodriguez、E. M. Olefirowicz、Ernest L. Eliel

  DOI：10.1021/jo00041a029

  日期：1992.7