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    首页 分子通 (R)-2-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-piperidine

    (R)-2-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-piperidine | 1089729-86-1

    分子结构分类

    有机化合物 - 有机杂环化合物 - 噻吩并咪唑类
    中文名称
    ——
    中文别名
    ——
    英文名称
    (R)-2-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-piperidine
    英文别名
    2-[(2R)-piperidin-2-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole
    (R)-2-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-piperidine化学式
    CAS
    1089729-86-1
    化学式
    C15H15F3N2OS
    mdl
    ——
    分子量
    328.358
    InChiKey
    WOVUPILAIVUBHX-GFCCVEGCSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      4.1
    • 重原子数：
      22
    • 可旋转键数：
      3
    • 环数：
      3.0
    • sp3杂化的碳原子比例：
      0.4
    • 拓扑面积：
      62.4
    • 氢给体数：
      1
    • 氢受体数：
      7

    文献信息

    • PIPERIDINE-AMIDE DERIVATIVES
      申请人：Andjelkovic Mirjana
      公开号：US20080300279A1
      公开（公告）日：2008-12-04
      The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R 1 , R 2 , X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and may be used to treat diseases associated with L-CPT1.
      这项发明涉及式（I）中的新型哌啶酰胺衍生物，其中R1、R2、X和Y如描述和权利要求中定义，并且其生理上可接受的盐和酯。这些化合物抑制L-CPT1，可用于治疗与L-CPT1相关的疾病。
    • US8039487B2
      申请人：——
      公开号：US8039487B2
      公开（公告）日：2011-10-18
    • [EN] PIPERIDINE-AMIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE PIPÉRIDINE-AMIDE
      申请人：HOFFMANN LA ROCHE
      公开号：WO2008145596A1
      公开（公告）日：2008-12-04
      [EN] The invention is concerned with novel piperidine- amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
      [FR] L'invention concerne des nouveaux dérivés de pipéridine-amide de formule (I) dans laquelle R1, R2, X et Y sont tels que définis dans la description et dans les revendications, ainsi que leurs sels et esters physiologiquement acceptables. Ces composés inhibent L-CPT1 et peuvent être utilisés comme médicaments.
    查看更多

    同类化合物

    沙维拉唑 4H-吡咯并[1,2-a]噻吩并[3,2-D]咪唑 3H-噻吩并[2,3-d]咪唑-5-羧酸 3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮 2-(氯甲基)-1H-噻吩并[3,4-d]咪唑 1H-噻吩并[3,2-D]咪唑-2(3H)-酮 1H-噻吩并[2,3-d]咪唑,1-乙烯基-(9CI) 1H-噻吩并(3,4-d)咪唑,2-(((5-甲基-2-吡啶基)甲基)亚硫酰基)- 1-甲基-1H-噻吩并[2,3-D]咪唑基-2(3H)-酮 1-乙烯基-1H-噻吩并[2,3-d]咪唑-5-羧酸 1,3-二氢噻吩并[3,4-d]咪唑-2-硫酮 2-(3-Chloro-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(1-isopropyl-pyrrolo[3,2-b]pyridin-5-yl)-4-methyl-1,3-thiazole-5-carboxylic acid isopropyl ester 2-(3-cyano-1-isopropyl-pyrrolo[3,2-b]pyridin-5-yl)-4-methyl-1,3-thiazole-5-carboxylic acid isopropyl ester 2-(5-Methoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(4-ethoxy-benzyl)-1(3)H-thieno[2,3-d]imidazole 3,4,8-triamino-1H-pyrazolo<3,4-d>thieno<2,3-b>pyridin-7-carbonsaeure-ethylester 1-[2-(5-Methyl-pyridin-2-ylmethanesulfinyl)-3H-thieno[3,4-d]imidazol-6-yl]-ethanone 2-Oxo-2,3-dihydro-4-methyl-1H-thieno<3,4-d>imidazol 2-[4-(2,2,2-trifluoroethyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 1,2-dimethyl-N-{2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]ethyl}-1H-thieno[3, 4-d]imidazole-4-carboxamide 2-[4-(2,2,3,3,3-pentafluoropropyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-(3-Fluoro-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-[(3-methoxypyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole 2-(5-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrobromide 2-(3,5-Dimethyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-5-[(thiophen-2-ylcarbonyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 1H-thieno[3,4-d]imidazol-2(3H)-one 2-(4-piperidino-3-chloro-2-picolylmercapto)-1H-thieno[3,4-d]imidazole 4,6-Dimethyl-2-(pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-(3-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride ethyl 2-benzylthio-1-methoxymethyl-1H-thieno<2,3-d>imidazole-5-carboxylate 2-(6-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-(4-Methoxy-pyridin-2-ylmethylsulfanyl)-4,6-dimethyl-1H-thieno[3,4-d]imidazole; hydrochloride 2-(4-Ethoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-[(3-methylpyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole Methyl 2-oxo-1,3-dihydrothieno[3,4-d]imidazole-4-carboxylate 2-oxo-2,3-dihydro-4-(δ-N-methylcarbamidobutyl)-1H-thieno<3,4-d>imidazole methyl 2-hexylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate methyl 2-butylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate dimethyl 4-methyl-4H-pyrrolo[3,2-d][1,3]thiazole-2,5-dicarboxylate 2-[4-(2,2,3,3,4,4,4-heptafluorobutyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-(3,5-Dimethyl-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 4,6-Dimethyl-2-(pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-Ethoxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-Methoxy-pyridin-2-ylmethanesulfinyl)-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid amide 4-phenyl-2-(pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-4-(4-methoxyphenyl)-1H-thieno[3,4-d]imidazole

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