2-isopropyl-4,4-dimethyl-4,5-dihydro-1H-imidazole | 72470-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 2-isopropyl-4,4-dimethyl-4,5-dihydro-1H-imidazole
• 英文别名: 5,5-Dimethyl-2-propan-2-yl-1,4-dihydroimidazole
• CAS: 72470-28-1
• 化学式: C₈H₁₆N₂
• mdl: MFCD19221360
• 分子量: 140.228
• InChiKey: XXZHTLSSICJYKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Z)-3-[(2-amino-2-methylpropyl)amino]-4-methylpent-2-enenitrile 以76%的产率得到
  参考文献：
  名称：

  LANDOR S. R.; LANDOR P. D.; FOMUM Z. T.; MPANGO G. W. B., J. CHEM. SOC. PERKIN TRANS., PART 1, 1979, NO 9, 2289-2293

  摘要：

  DOI：

文献信息

• Phenethylamide derivatives with kinase inhibitory activity
  申请人：Gould E. Alexandra

  公开号：US20080064729A1

  公开（公告）日：2008-03-13

  The present invention provides novel phenethylamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型的苯乙酰胺化合物，可用作蛋白激酶的抑制剂。该发明还提供了包括该化合物的药物组合物，以及在治疗各种疾病中使用该组合物的方法。
• Antifungal agents
  申请人：Greenlee Mark L.

  公开号：US20100113439A1

  公开（公告）日：2010-05-06

  Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

  本文披露了恩福马富金的新型衍生物，以及它们的药用盐、水合物和前药。还公开了包含这些化合物的组合物、制备这些化合物的方法以及将这些化合物用作抗真菌剂和/或(1,3)-β-D-葡聚糖合酶抑制剂的方法。这些公开的化合物、它们的药用盐、水合物和前药，以及包含这些化合物、盐、水合物和前药的组合物，可用于治疗和/或预防真菌感染及相关疾病和病况。
• Bicyclic compounds with kinase inhibitory activity
  申请人：Calderwood F. Emily

  公开号：US20070149533A1

  公开（公告）日：2007-06-28

  The present invention provides novel bicyclic compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新颖的双环化合物，可用作蛋白激酶抑制剂。本发明还提供了包括本发明化合物的制药组合物以及使用该组合物治疗各种疾病的方法。
• TREATMENT OF ACANTHAMOEBA OR BALAMUTHIA TROPHOZOITES AND/OR CYSTS
  申请人：GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US20220096441A1

  公开（公告）日：2022-03-31

  Compounds, compositions, and methods for the treatment of infections caused by Acanthamoeba or Balamuthia mandrillaris trophozoites and/or cysts and for the disinfection of solids and/or liquids, such as medical and personal care items, for example contact lenses, that may harbor Acanthamoeba trophozoites and/or cysts are provided.
• US7652041B2
  申请人：——

  公开号：US7652041B2

  公开（公告）日：2010-01-26