Oleoylphosphate | 62649-54-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Oleoylphosphate
• 英文别名: phosphono (Z)-octadec-9-enoate
• CAS: 62649-54-1
• 化学式: C₁₈H₃₅O₅P
• 分子量: 362.4
• InChiKey: VHHMNNRGNQWMKU-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• LPA receptor agonists and antagonists and methods of use
  申请人：Miller D. Duane

  公开号：US20060009507A1

  公开（公告）日：2006-01-12

  The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明涉及公式（I）所示的化合物，以及包括这些化合物的制药组合物。还公开了使用这些化合物的方法，这些化合物具有作为LPA受体的激动剂或拮抗剂的活性；这些方法包括抑制LPA受体上的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗凋亡或在细胞、组织或器官中保持或恢复功能，培养细胞，保护器官或组织功能，以及治疗皮肤病症。
• LPA Receptor Agonists and Antagonists and Methods of Use
  申请人：Miller D. Duane

  公开号：US20080090783A1

  公开（公告）日：2008-04-17

  Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明涉及化合物(I)及包含该化合物的药物组合物。还揭示了使用这些化合物的方法，这些方法具有作为LPA受体激动剂或拮抗剂的活性；这些方法包括抑制LPA受体上的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗创伤，治疗凋亡或保护或恢复细胞、组织或器官的功能，培养细胞，保护器官或组织功能，以及治疗皮肤病症。
• LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE
  申请人：Miller Duane D.

  公开号：US20120135967A1

  公开（公告）日：2012-05-31

  Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明公开了按照公式(I)的化合物，以及包括这些化合物的制药组合物。还公开了使用这些化合物的方法，这些化合物具有作为LPA受体的激动剂或拮抗剂的活性。这些方法包括抑制LPA在LPA受体上的活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗凋亡或保护或恢复细胞、组织或器官的功能，培养细胞，保护器官或组织功能以及治疗皮肤病条件。
• Liquid single reagent for assays
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0243001A1

  公开（公告）日：1987-10-28

  Assay methods and compositions are provided for determining an analyte in a sample suspected of containing the analyte. The composition comprises in a novel single liquid reagent at least one specific binding pair (sbp) member and its complementary member wherein at least one sbp member is reversibly confined in a material that temporarily renders the confined sbp member incapable of binding with its complementary sbp member. At least one of the sbp members is bound to a member of a signal producing system capable of producing a detectable signal in relation to the amount of analyte in the sample. The confinement is reversed, any remaining members of the signal producing system are added, and the signal produced in relation to the amount of analyte is measured.

  提供了测定疑似含有分析物的样品中分析物的检测方法和组合物。该组合物在新型单液试剂中包括至少一个特异性结合对（sbp）成员及其互补成员，其中至少一个 sbp 成员被可逆地限制在一种材料中，该材料可暂时使被限制的 sbp 成员无法与其互补的 sbp 成员结合。至少一个 sbp 成员与信号产生系统的一个成员结合，该信号产生系统能够产生与样品中分析物含量相关的可检测信号。反转封闭，添加信号产生系统的任何剩余成员，并测量与分析物含量相关的信号。
• POLYESTER RESIN COMPOSITION AND MOLDED PRODUCT THEREOF
  申请人：Toray Industries, Inc.

  公开号：EP4006103A1

  公开（公告）日：2022-06-01

  The present invention relates to a polyester resin composition and a molded product thereof. The polyester resin composition is obtained by compounding at least: (A) 100 parts by mass of a polybutylene terephthalate resin, (B) 15 to 100 parts by mass of an amorphous resin and (C) 0.01 to 5 parts by mass of an epoxy resin with a special structure, and the melting point of the polyester resin composition is greater than 210°C but less than 221°C. The polyester resin composition and the molded product thereof according to the present invention have excellent laser transmittance and can be used for various electrical mounting components for automobiles (various control units, various sensors, etc.), connectors, switch components, relay components, etc.

  本发明涉及一种聚酯树脂组合物及其模塑产品。该聚酯树脂组合物至少由以下材料混合而成：(A) 100 份（质量）聚对苯二甲酸丁二酯树脂；(B) 15 至 100 份（质量）无定形树脂；(C) 0.01 至 5 份（质量）具有特殊结构的环氧树脂，且该聚酯树脂组合物的熔点高于 210°C 但低于 221°C。根据本发明的聚酯树脂组合物及其模塑产品具有优异的激光透过率，可用于汽车的各种电气安装元件（各种控制单元、各种传感器等）、连接器、开关元件、继电器元件等。