Latonduine B

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: Latonduine B
• 英文别名: 12-amino-3,4-dibromo-7-oxo-5,8,11,13-tetrazatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene-14-carboxylic acid
• 化学式: C₁₁H₇Br₂N₅O₃
• 分子量: 417.01
• InChiKey: ARYHGXSLRQWMGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• SMALL MOLECULE CORRECTORS OF DELTAF508 CFTR TRAFFICKING
  申请人：Andersen Raymond

  公开号：US20100280004A1

  公开（公告）日：2010-11-04

  This invention provides compounds of Formula I. The compounds are correctors of ΔF508 CFTR trafficking. Also provided are uses of compounds of Formula I for treatment, as well as methods of treatment, of cystic fibrosis.
• [EN] SMALL MOLECULE CORRECTORS OF DELTAF508 CFTR TRAFFICKING<br/>[FR] PETITES MOLÉCULES CORRECTRICES DU TRANSPORT DE DELTAF508 CFTR
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2009003289A1

  公开（公告）日：2009-01-08

  This invention provides compounds of Formula I. The compounds are correctors of ΔF508 CFTR trafficking. Also provided are uses of compounds of Formula I for treatment, as well as methods of treatment, of cystic fibrosis.