Gluconic acid phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Gluconic acid phosphate
• 英文别名: phosphono 2,3,4,5,6-pentahydroxyhexanoate
• 化学式: C₆H₁₃O₁₀P
• 分子量: 276.14
• InChiKey: IMLGFCBIORERST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  185
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• [EN] DNA-PK INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTÉINE KINASE DÉPENDANTE DE L'ADN
  申请人：VERTEX PHARMA

  公开号：WO2019143678A1

  公开（公告）日：2019-07-25

  The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.

  本发明涉及作为DNA-PK抑制剂有用的化合物。该发明还提供了包括所述化合物的药学上可接受的组合物，以及在治疗各种疾病、状况或障碍中使用这些组合物的方法。
• Adenosine nucleobase editors and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US10113163B2

  公开（公告）日：2018-10-30

  The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins further comprise a nuclear localization sequence (NLS), and/or an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN).

  本发明提供的腺苷脱氨酶能够对 DNA 中的腺苷进行脱氨。本发明还提供了由 Cas9（例如 Cas9 nickase）结构域和腺苷脱氨酶组成的融合蛋白，腺苷脱氨酶能使 DNA 中的腺苷脱氨。在某些实施方案中，融合蛋白进一步包含核定位序列（NLS）和/或碱基修复抑制剂，如核酸酶死肌苷特异性核酸酶（dISN）。
• Nucleobase editors and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US10167457B2

  公开（公告）日：2019-01-01

  Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided.

  本公开的某些方面提供了用于核酸靶向编辑的策略、系统、试剂、方法和试剂盒，包括编辑细胞或受试者基因组内的单个位点，例如人类基因组内的单个位点。在一些实施方案中，提供了 Cas9 与核酸编辑蛋白或蛋白结构域（如脱氨酶结构域）的融合蛋白。在一些实施方案中，提供了用于靶向核酸编辑的方法。在一些实施方案中，提供了用于产生靶向核酸编辑蛋白（例如 Cas9 和核酸编辑蛋白或结构域的融合蛋白）的试剂和试剂盒。
• RNA-guided nucleases and active fragments and variants thereof and methods of use
  申请人：LifeEDIT Therapeutics, Inc.

  公开号：US11162114B2

  公开（公告）日：2021-11-02

  Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

  本研究提供了与感兴趣的目标序列结合的组合物和方法。这些组合物可用于裂解或修改感兴趣的靶序列、可视化感兴趣的靶序列以及修改感兴趣的序列的表达。组合物包括 RNA 引导的核酸酶多肽、CRISPR RNA、反式激活 CRISPR RNA、引导 RNA 和编码这些 RNA 的核酸分子。还提供了包含核酸分子的载体和宿主细胞。进一步提供了用于结合感兴趣的靶序列的 CRISPR 系统，其中 CRISPR 系统包括 RNA 引导的核酸酶多肽和一个或多个引导 RNA。
• Intracellular formation of peptide conjugates
  申请人：De Frees Shawn

  公开号：US20060177892A1

  公开（公告）日：2006-08-10

  The invention includes methods and compositions for forming peptide conjugates intracellularly having a covalent linkage between a modifying group and a glycosylated or non-glycosylated peptide. The modifying group is conjugated to the peptide via a glycosyl linking group interposed between and covalently linked to both the peptide and the modifying group.

  本发明包括在细胞内形成肽共轭物的方法和组合物，这些肽共轭物具有修饰基团与糖基化或非糖基化肽之间的共价连接。修饰基团通过插在肽和修饰基团之间并与之共价连接的糖基连接基团与肽共轭。