(2,3,4-Trihydroxy-6-oxohexyl) dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: (2,3,4-Trihydroxy-6-oxohexyl) dihydrogen phosphate
• 化学式: C₆H₁₃O₈P
• 分子量: 244.14
• InChiKey: MBPFNOMGYSRGQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• IMPROVED ALPHA BETA T PROCESSED CELL PRODUCTION METHOD
  申请人：Osaka University

  公开号：EP3750988A1

  公开（公告）日：2020-12-16

  Provided are a production method for cytotoxic T cells with increased recognition of cancer cells, a cancer treatment drug including said cytotoxic T cells, and a treatment method using said treatment drug.

  本发明提供了一种可提高对癌细胞识别能力的细胞毒性 T 细胞的生产方法、一种包括所述细胞毒性 T 细胞的癌症治疗药物，以及一种使用所述治疗药物的治疗方法。
• DRUG DELIVERY SYSTEM USING SOLUTION
  申请人：Kyoto University

  公开号：EP3888693A1

  公开（公告）日：2021-10-06

  The present invention provides a means excellent in efficiency of introduction of a nucleic acid, a protein, a complex thereof, or the like into cells, in particular a method using a solution for transduction. In the method for transducing a molecule(s) of interest into a cell according to the present invention, comprising a step of contacting the cell with the molecule(s) of interest and a solution for transduction according to the present invention, the solution for transduction contains: at least one of the following (A1) to (A5); and (B) a salt: (A1) a compound represented by formula (I) excluding a predetermined compound, or a salt thereof; (A2) a compound represented by formula (II), or a salt thereof; (A3) a nucleic-acid base or the like, or a salt thereof; (A4) a compound represented by formula (III), or a salt thereof, excluding malic acid; and (A5) at least one selected from the group consisting of creatinine, hydroxyproline, 1,3-butanediol, trientine, D-cellobiose, 1,3-dimethylurea, pantolactone and trimethadione, or a salt thereof.

  本发明提供了一种将核酸、蛋白质、其复合物或类似物高效导入细胞的方法，特别是一种使用转导溶液的方法。在根据本发明的将感兴趣的分子转导到细胞中的方法中，包括将细胞与感兴趣的分子和根据本发明的转导用溶液接触的步骤，转导用溶液包含：以下(A1)至(A5)中的至少一种；和(B)一种盐：(A1)式(I)代表的化合物，不包括预定化合物，或其盐； (A2)式(II)代表的化合物，或其盐； (A3)核酸碱或类似物，或其盐；(A4) 由式（III）代表的化合物，或其盐，不包括苹果酸；以及 (A5) 至少一种选自肌酸酐、羟脯氨酸、1,3-丁二醇、三戊二酸、D-纤维二糖、1,3-二甲基脲、泛醇内酯和三甲二酮组成的组，或其盐。
• IMPROVED ALPHA-BETA T PROCESSED CELL PRODUCTION METHOD
  申请人：OSAKA UNIVERSITY

  公开号：US20210002611A1

  公开（公告）日：2021-01-07

  Provided are a production method for cytotoxic T cells with increased recognition of cancer cells, a cancer treatment drug including said cytotoxic T cells, and a treatment method using said treatment drug.
• [EN] IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS<br/>[FR] IDENTIFICATION ET MODULATION CIBLÉE DE RÉSEAUX DE SIGNALISATION GÉNIQUE
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2018204764A1

  公开（公告）日：2018-11-08

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
• [EN] IMPROVED αβ T PROCESSED CELL PRODUCTION METHOD<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRODUCTION DE LYMPHOCYTES T TRAITÉS αβ<br/>[JA] 改良されたαβＴ加工細胞製造方法
  申请人：UNIV OSAKA

  公开号：WO2019156145A1

  公开（公告）日：2019-08-15

  がん細胞に対する認識を高めた細胞傷害性Ｔ細胞の製造方法、該細胞傷害性Ｔ細胞を含むがん治療薬、ならびに該治療薬を用いた治療方法を提供する。