9,10-Dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-4,5,14,15-tetrol

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 二苯并环辛二烯木脂素
• 英文名称: 9,10-Dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-4,5,14,15-tetrol
• 化学式: C₁₈H₂₀O₄
• 分子量: 300.3
• InChiKey: QAIDKUGAYKKTCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Inhibitors of microbially induced amyloid
  申请人：Axial Therapeutics, Inc

  公开号：US11147792B2

  公开（公告）日：2021-10-19

  The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.

  本公开提供了预防、改善或减轻与微生物诱导的淀粉样蛋白形成相关的一种或多种神经紊乱的方法和组合物。本发明公开了抑制、改善、降低淀粉样蛋白紊乱的可能性、延迟淀粉样蛋白紊乱的发生、治疗或预防淀粉样蛋白紊乱的方法。本发明公开了鉴定能够抑制微生物诱导的淀粉样纤维形成的化合物的方法。
• INHIBITORS OF MICROBIALLY INDUCED AMYLOID
  申请人：Axial Biotherapeutics, Inc.

  公开号：US20200163933A1

  公开（公告）日：2020-05-28

  The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.