dl-Cepharamin | 24048-61-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈苏巴南生物碱
• 英文名称: dl-Cepharamin
• 英文别名: (-)-Cepharamine；3-hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[8.4.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one
• CAS: 24048-61-1
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: RARWEROUOQPTCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NF-kB activity inhibitor
  申请人：Kaken Shoyaku Co., Ltd.

  公开号：EP0931544A2

  公开（公告）日：1999-07-28

  This invention relates to an NF-κB activity inhibitor which contains alkaloids originated from a plant belonging to the genus Stephania of the family Menspermaceae, derivatives thereof and salts thereof, as the active components, to an agent for use in the treatment and prevention of diseases upon which the NF-κB activity inhibiting action is effective and to an inhibitor of the expression of related genes. Since said active components exert an action to inhibit transcription of DNA having an NF-κB recognition sequence by inhibiting the activity of NF-κB, the drug of the present invention can inhibit expression of genes of certain substances such as cytokines, inflammatory cytokine receptor antagonists, MHC class I, MHC class II, β2 microglobulin, immunoglobulin light chain, serum amyloid A, angiotensinogen, complement B, complement C4, C-myc gene, HIV, SV40, CMV, adenovirus and the like, so that the inventive drug is useful in treating and/or preventing various diseases in which these substances are taking roles.

  本发明涉及一种NF-κB活性抑制剂，其活性成分含有源自一种属于孟婆子科斯蒂芬尼亚属植物的生物碱、其衍生物及其盐类，涉及一种用于治疗和预防NF-κB活性抑制作用有效的疾病的药物，还涉及一种相关基因表达抑制剂。MHCⅠ类、MHCⅡ类、β2微球蛋白、免疫球蛋白轻链、血清淀粉样蛋白A、血管紧张素原、补体B、补体C4、C-myc基因、HIV、SV40、CMV、腺病毒等，因此本发明药物可用于治疗和/或预防这些物质起作用的各种疾病。
• Topical formulations and methods of use
  申请人：Morariu Marius

  公开号：US20060216251A1

  公开（公告）日：2006-09-28

  A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-1-carnitine, and 1-carnosine.

  本发明提供了一种外用组合物，该组合物包含硫辛酸、肉毒碱和肉毒碱，并以适合外用的载体形式存在，还提供了一种治疗皮肤的方法。本组合物有助于改善以皱纹和失去弹性为特征的老化皮肤的外观。优选成分包括 R-硫辛酸或 R-二氢硫辛酸、乙酰基-1-肉碱和 1-肉碱。
• Methods of Treating Skin
  申请人：Morariu Marius

  公开号：US20100272790A1

  公开（公告）日：2010-10-28

  A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-l-carnitine, and l-carnosine.
• METHODS OF TREATING SKIN
  申请人：Tracie Martyn International, Inc.

  公开号：US20140155961A1

  公开（公告）日：2014-06-05

  A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-l-carnitine, and l-carnosine.
• COMPOSITION FOR TREATMENT OF HAIR LOSS AND REGROWTH STIMULATION
  申请人：Nina Elya Ltd.

  公开号：US20180098933A1

  公开（公告）日：2018-04-12

  This invention is directed to a composition for treating and preventing hair loss in male and female, for regrowth stimulation of hair in male and female, for replenishing the previously colored hair in male and female, and for stimulation of healthy and strong finger nail growth, wherein the composition is a nutrition supplement.