2,4,5,6,7-Pentahydroxyhexahydro-2H-1,3,2lambda~5~-benzodioxaphosphol-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2,4,5,6,7-Pentahydroxyhexahydro-2H-1,3,2lambda~5~-benzodioxaphosphol-2-one
• 英文别名: 2-hydroxy-2-oxo-3a,4,5,6,7,7a-hexahydrobenzo[d][1,3,2]dioxaphosphole-4,5,6,7-tetrol
• 化学式: C₆H₁₁O₈P
• 分子量: 242.12
• InChiKey: SXHMVNXROAUURW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• IMMUNOGENIC COMPOSITIONS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF
  申请人：THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

  公开号：EP1545599B1

  公开（公告）日：2015-04-29
• Methods, treatments, and compositions for modulating Hedgehog pathways
  申请人：Jennings-Spring Barbara L.

  公开号：US20080138379A1

  公开（公告）日：2008-06-12

  The present invention relates to prevention of congenital deformations The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events gene expression during prenatal development, post-natal development and during development in the adult organism.
• Method of treatment and compositions of D-chiro inositol and phosphates thereof
  申请人：Jennings-Spring Barbara L.

  公开号：US20080103116A1

  公开（公告）日：2008-05-01

  The present invention relates to the use of D-chiroinositol or a phosphate thereof in combination with folate for the reduction or prevention of congenital deformations such as anorectal malformations, neural tube defects, cleft-lip, cleft palate, and other birth defects. The invention further relates to the use of D-chiroinositol or a phosphate thereof in quieting or preventing the sensitivity of breast tissue to estrogenic, progestogenic, and or anti-androgenic insult, whether from environmental, dietary, or medicinal sources. Co-therapies as well as combination products of D-chiro-inositol (or a phosphate thereof) with at least one of (a) a folate source and (b) one or more of an estrogenic substance, a progestogenic substance, and/or an antiandrogenic substance are also claimed.
• Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
  申请人：Jennings Barbara Brooke

  公开号：US20090214474A1

  公开（公告）日：2009-08-27

  The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism.
• Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development
  申请人：Jennings Barbara Brooke

  公开号：US20160143927A1

  公开（公告）日：2016-05-26

  The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.