羟基苯胺芥菜磷酸酯 | 46900-82-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 羟基苯胺芥菜磷酸酯
• 英文名称: Phosphoric acid mono-{4-[bis-(2-chloro-ethyl)-amino]-phenyl} ester
• 英文别名: 4-[Bis(2-chloroethyl)amino]phenyl dihydrogen phosphate；[4-[bis(2-chloroethyl)amino]phenyl] dihydrogen phosphate
• CAS: 46900-82-7
• 化学式: C₁₀H₁₄Cl₂NO₄P
• 分子量: 314.105
• InChiKey: LJMDUALNSRAEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents
  申请人：Denny William Alexander

  公开号：US20100010094A1

  公开（公告）日：2010-01-14

  The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzyme-prodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.

  本发明涉及新型的硝基苯基芥和硝基苯基环氧丙烷醇，它们对应的磷酸盐，以及它们作为靶向细胞毒性药物的使用；作为缺氧肿瘤中的生物还原药物，并结合硝酸还原酶酶使用于细胞消融，包括基因定向酶前药物治疗（GDEPT）和抗体定向酶前药物治疗（ADEPT）。
• Intelligent Nanomedicine Integrating Diagnosis And Therapy
  申请人：Li Na

  公开号：US20090202507A1

  公开（公告）日：2009-08-13

  A method of controlling the activity of a biologically active compound. The method concerns an oligonucleotide-based compound, comprising a hairpin-forming oligonucleotide, an effector moiety physically associated with the oligonucleotide, where the effector moiety possesses a biological activity, and a regulating moiety physically associated with the oligonucleotide, where the regulating moiety controls the biological activity of the effector moiety by interacting with the effector moiety. The oligonucleotide can assume a hairpin configuration, where the effector and regulating moieties interact, or an open configuration, where the effector and regulating moieties fail to interact. Depending on the nature of the effector and regulating moieties, either configuration can result in the expression of the biological activity of the effector moiety.
• US7629332B2
  申请人：——

  公开号：US7629332B2

  公开（公告）日：2009-12-08
• US8257918B2
  申请人：——

  公开号：US8257918B2

  公开（公告）日：2012-09-04