4-(3-methoxyphenyl)-thiomorpholine 1,1-dioxide | 1219600-61-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 4-(3-methoxyphenyl)-thiomorpholine 1,1-dioxide
• 英文别名: N-(3-methoxyphenyl)thiomorpholine 1,1-dioxide；4-(3-Methoxyphenyl)-1,4-thiazinane 1,1-dioxide
• CAS: 1219600-61-9
• 化学式: C₁₁H₁₅NO₃S
• 分子量: 241.311
• InChiKey: QQGQSFFABKEBCV-UHFFFAOYSA-N

物化性质

• 熔点：
  72.9-76.2 °C
• 沸点：
  478.6±40.0 °C(predicted)
• 密度：
  1.255±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二乙烯基砜 、 3-硝基苯甲醚 在 indium 、 氯化铵 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 以48%的产率得到4-(3-methoxyphenyl)-thiomorpholine 1,1-dioxide
  参考文献：
  名称：

  One-Pot Aryl-1,4-thiomorpholine 1,1-Dioxide Synthesis via Double 1,4-Addition of in situ Reduced Nitroarenes to Divinyl Sulfones

  摘要：

  One-pot reduction-triggered double aza-Michael type 1,4-addition reactions of various nitroarenes to divinyl sulfones were investigated. In the presence of indium/AcOH in MeOH or in sat. aq NH(4)Cl/MeOH, nitroarenes and divinyl sulfones were cyclized to give 1,4-thiomorpholine 1,1-dioxides.

  DOI：

  10.3987/com-09-11858

文献信息

• Boric Acid / Glycerol as an Efficient Catalyst for Synthesis of Thiomorpholine 1,1-Dioxide by Double Michael Addition Reaction in Water
  作者：Azim Ziyaei Halimehjnai、Seyedmorteza Hosseyni、Hadi Gholami、Mohammed M. Hashemi

  DOI：10.1080/00397911.2011.594930

  日期：2013.1

  Abstract Thiomorpholine 1,1-dioxides were prepared with double Michael addition reaction of aromatic amines to divinyl sulfone catalyzed by boric acid / glycerol in water. This catalyst system was also used for the Michael addition reaction of aromatic amines to electron-deficient alkenes. The reaction is simple and green and gives good to excellent yields. GRAPHICAL ABSTRACT

  摘要 以硼酸/甘油在水中催化芳香胺与二乙烯基砜的双迈克尔加成反应制备了硫代吗啉1,1-二氧化物。该催化剂体系也用于芳香胺与缺电子烯烃的迈克尔加成反应。该反应简单且绿色，产率高。图形概要
• US4006127A
  申请人：——

  公开号：US4006127A

  公开（公告）日：1977-02-01
• One-Pot Aryl-1,4-thiomorpholine 1,1-Dioxide Synthesis via Double 1,4-Addition of in situ Reduced Nitroarenes to Divinyl Sulfones
  作者：Byeong Hyo Kim、Joon Hee Han、Jaehwan Choi、Young Moo Jun、Byung Min Lee

  DOI：10.3987/com-09-11858

  日期：——

  One-pot reduction-triggered double aza-Michael type 1,4-addition reactions of various nitroarenes to divinyl sulfones were investigated. In the presence of indium/AcOH in MeOH or in sat. aq NH(4)Cl/MeOH, nitroarenes and divinyl sulfones were cyclized to give 1,4-thiomorpholine 1,1-dioxides.