(S)-ethyl methyl isopropyl phosphate | 57557-33-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: (S)-ethyl methyl isopropyl phosphate
• 英文别名: (-)-(R)-Aethyl-methyl-isopropylphosphat；(S)-(-)-Aethyl-isopropyl-methylphosphat；(R)-phosphoric acid ethyl ester isopropyl ester methyl ester；ethyl methyl propan-2-yl phosphate
• CAS: 57557-33-2
• 化学式: C₆H₁₅O₄P
• 分子量: 182.156
• InChiKey: RSVFCXFHYGCMFA-LLVKDONJSA-N

物化性质

• 沸点：
  206.1±8.0 °C(Predicted)
• 密度：
  1.064±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  R-(+)-ethyl OS-dimethyl phosphorothioate 、 sodium isopropylate 生成 (S)-ethyl methyl isopropyl phosphate
  参考文献：
  名称：

  Hall,C.R.; Inch,T.D., Journal of the Chemical Society. Perkin transactions I, 1979, p. 1104 - 1111

  摘要：

  DOI：

文献信息

• Stereospecific synthesis from carbohydrate precurors of (R)- and (S)-ethyl isopropyl methyl phosphate and other optically active neutral phosphorus esters
  作者：C. Richard Hall、Thomas D. Inch、Gilbert J. Lewis、Rosemary A. Chittenden

  DOI：10.1039/c39750000720

  日期：——

  Stereospecific syntheses starting from carbo-hydrate precursors of (+)-(R) and (–)-(S)-ethyl iso-propyl methyl phosphates, (+)-(R)-O-ethyl O,S-dimethyl phosphorothioate, and (+)-(R)-ethyl methyl methyl-phosphonate are described; the enantiomeric purity of these compounds was determined by an n.m.r. method involving the use of tris-[3-(heptafluoro-n-propylhydroxy-methylene)-(+)-camphorato]europium(III)

  从（+）-（R）和（-）-（S）-乙基异丙基甲基磷酸酯，（+）-（R）-O-乙基O，S-二甲基硫代磷酸酯，描述了（+）-（R）-甲基膦酸乙酯。这些化合物的对映体纯度是通过核磁共振法测定的，该方法涉及使用三-[3-（七氟-正丙基羟基-亚甲基）-（+）-樟脑灯] eur（III）。
• Stereochemical consequences of the use of chiral N-phosphoryl oxazolidinones in the attempted kinetic resolution of bromomagnesium alkoxides
  作者：Simon Jones、Dimitrios Selitsianos

  DOI：10.1016/j.tetasy.2005.08.025

  日期：2005.9

  A number of chiral N-phosphoryl oxazolidinones have been prepared and evaluated as asymmetric phosphoryl transfer agents with the magnesium alkoxide of 1-phenyl ethanol. The reaction proceeded with little stereo selection, which was shown to be a consequence of the reaction mechanism that occurs with inversion of configuration at phosphorus consistent with in-line attack opposite the leaving group. (C) 2005 Elsevier Ltd. All rights reserved.
• Cooper,D.B. et al., Journal of the Chemical Society. Perkin transactions I, 1977, p. 1969 - 1980
  作者：Cooper,D.B. et al.

  DOI：——

  日期：——
• NAKAYAMA, KENSAKU;THOMPSON, W. J., J. AMER. CHEM. SOC., 112,(1990) N9, C. 6936-6942
  作者：NAKAYAMA, KENSAKU、THOMPSON, W. J.

  DOI：——

  日期：——
• Hall,C.R.; Inch,T.D., Journal of the Chemical Society. Perkin transactions I, 1979, p. 1104 - 1111
  作者：Hall,C.R.、Inch,T.D.

  DOI：——

  日期：——