c-HMBPP | 876060-89-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: c-HMBPP
• 英文别名: (2E)-1-hydroxy-2-methyl-2-pentenyl-pyrophosphonic acid；(2E)-1-hydroxy-2-methylpent-2-enyl-pyrophosphonate；[(E)-4-Methyl-5-Oxidanyl-Pent-3-Enyl]-Phosphonooxy-Phosphinic Acid；[(E)-5-hydroxy-4-methylpent-3-enyl]-phosphonooxyphosphinic acid
• CAS: 876060-89-8
• 化学式: C₆H₁₄O₇P₂
• 分子量: 260.12
• InChiKey: YYYUHBYKZCBOPY-ZZXKWVIFSA-N

物化性质

• 沸点：
  507.6±60.0 °C(Predicted)
• 密度：
  1.570±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  c-HMBPP 、 N,N'-二苄基乙二胺 以 乙醇 、 水 为溶剂， 生成 (2E)-1-hydroxy-2-methyl-2-pentenyl-pyrophosphonic acid, N,N'-dibenzylethylenediammonium salt
  参考文献：
  名称：

  WO2007/39635

  摘要：

  公开号：
• 作为产物：
  描述：

  ammoium (E)-5-hydroxy-4-methylpent-3-enyl pyrophosphonate 在 DOWEX 50WX₈-100 cationic resin (H+ form) 作用下， 以 水 为溶剂， 生成 c-HMBPP
  参考文献：
  名称：

  WO2007/39635

  摘要：

  公开号：

文献信息

• [EN] NOVEL POLYMORPHIC FORM OF CHDMAPP, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] NOUVELLE FORME POLYMORPHE DE CHDMAPP, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE LA CONTENANT
  申请人：INNATE PHARMA

  公开号：WO2010029062A1

  公开（公告）日：2010-03-18

  The present invention relates to novel polymorphs of (2E)-1-hydroxy-2-methylpent-2-enyl-pyrophosphonate disodium (CHDMAPP-Na2), to the process for preparing them and to the pharmaceutical compositions containing them.

  本发明涉及(2E)-1-羟基-2-甲基戊-2-烯基焦磷酸二钠(CHDMAPP-Na2)的新型多晶形态、其制备方法以及含有它们的药物组合物。
• NOVEL POLYMORPHIC FORM OF CHDMAPP, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Innate Pharma

  公开号：EP2324040B1

  公开（公告）日：2014-01-01
• Composition and method for the treatment of carcinoma
  申请人：Romagne Francois

  公开号：US20070134273A1

  公开（公告）日：2007-06-14

  The present invention relates to compositions and methods useful for treating a carcinoma or viral infection in mammals, including humans. The methods and compositions typically comprise use of an immunogenic or immunomodulatory compound, and a gamma delta T cell activator, such that the composition is effective for treating a carcinoma or viral infection. In a preferred aspect of the invention, the methods comprise use of a gamma delta T cell activator and a Mycobacterium antigen, which for example is an attenuated strain of Mycobacterium bovis ( Bacillus Calmette-Guerin (BCG)).
• Adjuvant Composition and Methods for Its Use
  申请人：Tiollier Jerome

  公开号：US20070218086A1

  公开（公告）日：2007-09-20

  The present invention is directed to a vaccine adjuvant which improves the vaccine potency. More specifically, the present invention is directed to the use of a γδT lymphocyte activator as vaccine adjuvant to promote and enhance antigen specific immunological responses, as well as a vaccine composition comprising a γδT lymphocyte activator.
• Organophosphorous Compounds for the Activation of Gamma/Delta T Cells
  申请人：Jomaa Hassan

  公开号：US20080249067A1

  公开（公告）日：2008-10-09

  The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the prophylaxis and treatment of diseases in humans and animals.