4-aminophenol phosphate | 52331-30-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 4-aminophenol phosphate
• 英文别名: 4-aminophenyl phosphate；p-aminophenyl phosphate；p-aminophenylphosphate；4-APP；phosphoric acid mono-(4-amino-phenyl ester)；Phosphorsaeure-mono-(4-amino-phenylester)；(4-aminophenyl) dihydrogen phosphate
• CAS: 52331-30-3
• 化学式: C₆H₈NO₄P
• 分子量: 189.108
• InChiKey: FXZCCINCKDATPA-UHFFFAOYSA-N

物化性质

• 沸点：
  441.9±47.0 °C(Predicted)
• 密度：
  1.597±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  4-aminophenol phosphate 在 magnesium chloride 、 alkaline phosphatase 、 N-[3-(三甲氧基硅基)丙基]乙二胺 作用下， 以 水 为溶剂， 反应 1.5h， 生成 对氨基苯酚
  参考文献：
  名称：

  碱性磷酸酶触发的含硅纳米粒子的原位形成，用于荧光和比色双通道免疫测定。

  摘要：

  在可及的条件下，用酶触发的原位发色和/或发荧光反应对于开发酶活性和相关的光谱分析具有重要意义。在这里，我们描述了一种简便的一锅法合成策略，该方法通过将N- [3-（三甲氧基甲硅烷基）丙基]乙二胺与对氨基苯甲酸酯混合来制备具有黄绿色荧光和橙红色的含硅纳米粒子-氨基苯酚（AP）在温和的水溶液中。受AP调节的简单合成程序以及由碱性磷酸酶（ALP）催化的4-氨基酚磷酸酯（APP）水解产生AP的启发，可以合理地设想和开发采用荧光和比色双读数ALP活性测定的方法。以APP为底物。在这种ALP活性测定法具有良好的分析性能并将其与酶联免疫吸附测定法（ELISA）成功结合之后，已构建了相应的基于荧光和比色法双读数ALP的ELISA方法，用于高灵敏度和定量测定人前列腺特异性抗原（PSA），是人血清中前列腺癌的关键生物标志物。

  DOI：

  10.1021/acs.analchem.0c00224
• 作为产物：
  描述：

  磷酸单硝基苯基酯 生成 4-aminophenol phosphate
  参考文献：
  名称：

  947.芳香胺的氧化。第五部分。过磷酸的氧化

  摘要：

  DOI：

  10.1039/jr9570004689

文献信息

• Use of metabolic phenotyping in individualized treatment with amonafide
  申请人：McGill University

  公开号：US20030190671A1

  公开（公告）日：2003-10-09

  The invention relates to the individualization of therapy on the basis of a phenotypic profile of an individual. More specifically, the present invention relates to the use of metabolic phenotyping for the individualization of treatment with the drug, amonafide.

  该发明涉及根据个体的表型特征个性化治疗。更具体地说，本发明涉及利用代谢表型来个性化阿莫那非德药物治疗。
• Multiple determinants for metabolic phenotypes
  申请人：——

  公开号：US20030091975A1

  公开（公告）日：2003-05-15

  The invention relates to the determination of multiple phenotypic determinants for human drug metabolizing enzymes. More specifically, the present invention relates to the characterization of metabolic phenotypes based on phenotypic determinants and applications and uses thereof.

  这项发明涉及确定人类药物代谢酶的多个表型决定因素。更具体地说，本发明涉及基于表型决定因素对代谢表型进行表征以及其应用和用途。
• Hydrolyzed urea condensate fertilizer, fungicide and insecticide
  申请人：Blount H. David

  公开号：US20050019363A1

  公开（公告）日：2005-01-27

  Fertilizer, fungicide and insecticide compositions are produced by the process of this invention. The partially hydrolyzed urea condensates are produced by heating urea with a limited amount of water and continue heating until water reacts with the urea and the urea condensate with urea and the partially hydrolyzed urea. The partially hydrolyzed urea condensate may be used alone or may be mixed with or reacted with salt forming compounds and mixed with a fillers to produce a partially hydrolyzed urea condensate composition The partially hydrolyzed urea condensate salts of phosphorus, boron or sulfur containing compounds may also be used as the insecticide, fungicide and fertilizer compound in this invention.

  本发明的过程生产了肥料、杀菌剂和杀虫剂组合物。部分水解的尿素缩聚物是通过将尿素与有限量的水加热，并持续加热直到水与尿素反应，得到尿素缩聚物和部分水解的尿素。部分水解的尿素缩聚物可以单独使用，也可以与或反应成盐形成化合物并与填料混合以生产部分水解的尿素缩聚物组合物。本发明中也可以使用含磷、硼或硫化合物的部分水解尿素缩聚物盐作为杀虫剂、杀菌剂和肥料化合物。
• Highly Uniform Gold Nanobipyramids for Ultrasensitive Colorimetric Detection of Influenza Virus
  作者：Shaohua Xu、Wenjun Ouyang、Peisi Xie、Yi Lin、Bin Qiu、Zhenyu Lin、Guonan Chen、Longhua Guo

  DOI：10.1021/acs.analchem.6b03711

  日期：2017.2.7

  Gold nanoparticles (AuNPs) have been frequently utilized for the construction of diverse colorimetric biosensors. Normally, AuNPs with sharp edges could have better sensitivity. However, the poor monodipersity of AuNPs with sharp edges seriously confines their utility for colorimetric biosensing. Herein, we demonstrate the utility of highly uniform gold nanobipyramids (Au NBPs) for ultrasensitive colorimetric detection of H5N1 virus. The proposed method is based on the fact that alkaline phosphatase (ALP) could catalyze the decomposition of 4-aminophenyl phosphate (4-APP) to generate 4-aminophenol (4-AP), which would then reduce silver nitrate to metal silver and then deposited on Au NBPs. The metal silver shell coated on the Au NBPs changed the refractive index of gold and thus resulted in a blue shift of longitudinal localized surface plasmon resonance (LSPR) and accompanied a vivid color change. This method exhibited a higher sensitivity than that of other Au NPs such as gold nanorods due to the high-index-faceted on the tips of the Au NBPs. This method was used to detect the activity of ALP. It exhibited a linear range of 0.1–5 mU/mL with a limit of detection (LOD) of 0.086 mU/mL. Finally, the proposed method was used in immunoassay to detect H5N1 virus. The results showed that the corresponding linear range for the detection of H5N1 virus antigen was 0.001–2.5 ng/mL, and the LOD was determined to be 1 pg/mL, which is more sensitive than those in most of the colorimetric biosensors reported previously.

  金纳米粒子（AuNPs）经常被用于构建各种比色生物传感器。通常情况下，边缘锐利的 AuNPs 具有更好的灵敏度。然而，边缘锋利的 AuNPs 单分散性较差，严重限制了其在比色生物传感中的应用。在此，我们展示了高度均匀的金纳米双锥体（Au NBPs）在超灵敏比色检测 H5N1 病毒中的应用。我们提出的方法是基于碱性磷酸酶（ALP）能催化 4- 氨基苯基磷酸（4-APP）分解生成 4- 氨基苯酚（4-AP），然后将硝酸银还原成金属银并沉积在金纳米双金字塔上。镀在金 NBPs 上的金属银外壳改变了金的折射率，从而导致纵向局部表面等离子体共振（LSPR）蓝移，并伴随着鲜艳的颜色变化。与金纳米棒等其他金纳米粒子相比，由于金 NBPs 顶端的高折射率面，这种方法具有更高的灵敏度。该方法用于检测 ALP 的活性。其线性范围为 0.1-5 mU/mL，检出限（LOD）为 0.086 mU/mL。最后，将所提出的方法用于免疫测定法检测 H5N1 病毒。结果表明，该方法检测 H5N1 病毒抗原的线性范围为 0.001-2.5 纳克/毫升，检测限为 1 皮克/毫升，灵敏度高于之前报道的大多数比色生物传感器。
• MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS
  申请人：Adamczyk Maciej

  公开号：US20120115244A1

  公开（公告）日：2012-05-10

  Methods of assaying for (i) a pterin by immunoassay employing a pterin as capture agent, (ii) neopterin by chemiluminescent microparticle immunoassay (CMIA) employing an anti-neopterin antibody (Ab) as capture agent, (iii) neopterin by an immunoassay (IA) employing an acridinium (Acr)-labeled anti-neopterin Ab as conjugate, and (iv) neopterin by an IA employing Acr-labeled neopterin as tracer; an Acr-labeled anti-neopterin Ab; a conjugate/complex comprising anti-neopterin Ab and a carrier scaffold; a conjugated pterin; a conjugate comprising an Acr-labeled pterin and a carrier scaffold; an immunogen comprising neopterin and a carrier protein; a conjugate comprising such an immunogen and an Acr compound; an immunogen comprising a carrier protein and a neopterin hapten; a conjugate comprising such an immunogen and an Acr compound; a kit for assaying a pterin comprising a pterin as a capture agent and instructions for IA; and a kit for assaying neopterin comprising an anti-neopterin Ab as a capture agent and instructions for CMIA, neopterin comprising an Acr-labeled anti-neopterin Ab as a conjugate and instructions for IA, or Acr-labeled neopterin as a tracer and instructions for IA.

  测定(i)一种黄素的免疫测定方法，采用一种黄素作为捕获试剂，(ii)一种新生黄素的化学发光微粒免疫测定(CMIA)方法，采用一种抗新生黄素抗体(Ab)作为捕获试剂，(iii)一种新生黄素的免疫测定(IA)方法，采用一种荧光素(Acr)标记的抗新生黄素抗体作为结合物，以及(iv)一种新生黄素的免疫测定方法，采用Acr标记的新生黄素作为追踪物；一种Acr标记的抗新生黄素抗体；一种包含抗新生黄素抗体和载体支架的结合物/复合物；一种共轭的黄素；一种包含Acr标记的黄素和载体支架的结合物；一种含有新生黄素和载体蛋白的免疫原；一种包含这种免疫原和Acr化合物的结合物；一种含有载体蛋白和新生黄素半抗原的免疫原；一种包含这种免疫原和Acr化合物的结合物；一种黄素测定试剂盒，包括一种黄素作为捕获试剂和IA的说明书；以及一种新生黄素测定试剂盒，包括一种抗新生黄素抗体作为捕获试剂和CMIA的说明书，或者包括一种Acr标记的抗新生黄素抗体作为结合物和IA的说明书，或者包括一种Acr标记的新生黄素作为追踪物和IA的说明书。