2-(thiophen-3-yl)-4,5-dihydro-1,3-thiazole | 1318795-40-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚氨硫酯类
• 英文名称: 2-(thiophen-3-yl)-4,5-dihydro-1,3-thiazole
• 英文别名: 2-Thiophen-3-yl-4,5-dihydro-1,3-thiazole
• CAS: 1318795-40-2
• 化学式: C₇H₇NS₂
• 分子量: 169.271
• InChiKey: WIGNXBSYICAEJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  65.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴乙胺氢溴酸盐 、 噻吩-3-硫代酰胺 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 2.0h， 以81%的产率得到2-(thiophen-3-yl)-4,5-dihydro-1,3-thiazole
  参考文献：
  名称：

  Easy access to thiazolines and thiazines via tandem S-alkylation-cyclodeamination of thioamides/haloamines

  摘要：

  这是首次报道通过硫代酰胺/卤胺的自催化、水辅助串联 S-烷基化-环脱氨基反应简便合成噻唑啉类和噻嗪类化合物。该反应清洁高效，产物处理简单，适用于多种底物。

  DOI：

  10.1039/c1gc15285h

文献信息

• Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
  申请人：FUJIFILM Corporation

  公开号：US11319347B2

  公开（公告）日：2022-05-03

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.

  本发明的目的是提供一种细胞膜渗透性极佳的新型环肽化合物、一种生产该化合物的方法、一种用于筛选的组合物以及一种选择与目标物质结合的环肽化合物的方法。根据本发明，提供了一种由式（1）表示的多肽化合物或其盐。式中的符号具有本申请说明书中定义的含义。
• PEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME, COMPOSITION FOR SCREENING USE, AND METHOD FOR SELECTING PEPTIDE COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20200040039A1

  公开（公告）日：2020-02-06

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.
• Easy access to thiazolines and thiazines via tandem S-alkylation-cyclodeamination of thioamides/haloamines
  作者：Uma Pathak、Shubhankar Bhattacharyya、Vishwanath Dhruwansh、Lokesh Kumar Pandey、Rekha Tank、Malladi V. S. Suryanarayana

  DOI：10.1039/c1gc15285h

  日期：——

  This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

  这是首次报道通过硫代酰胺/卤胺的自催化、水辅助串联 S-烷基化-环脱氨基反应简便合成噻唑啉类和噻嗪类化合物。该反应清洁高效，产物处理简单，适用于多种底物。