5,5-Dimethyl-2-piperidin-1-yl-1,3,2lambda5-dioxaphosphinane 2-oxide | 21139-45-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 5,5-Dimethyl-2-piperidin-1-yl-1,3,2lambda5-dioxaphosphinane 2-oxide
• 英文别名: 5,5-dimethyl-2-piperidin-1-yl-1,3,2λ5-dioxaphosphinane 2-oxide
• CAS: 21139-45-7
• 化学式: C₁₀H₂₀NO₃P
• 分子量: 233.247
• InChiKey: VPIAIVPXUZGEGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3,2-二氧磷杂环己烷-2-酮 在 四氯化碳 、 三乙胺 作用下， 以 氯仿 为溶剂， 生成 5,5-Dimethyl-2-piperidin-1-yl-1,3,2lambda5-dioxaphosphinane 2-oxide
  参考文献：
  名称：

  使用 atherton-todd 反应作为通用工具合成新的有机磷化合物

  摘要：

  本文讨论了七种有机磷化合物在 Atherton-Todd 条件下的行为。因此，系统研究了不同（苯）氧杂膦、二氧杂膦、二氧杂膦和二苯基氧化膦与三种亲核试剂的反应性和选择性。结果证明了 Atherton-Todd 反应对具有不同磷环境和反应性 PH 键的各种有机磷化合物的多功能性。本文研究的亲核试剂被选为胺类和醇类的模型底物。由于有机磷分子是重要且用途广泛的化合物，因此对于广泛的应用领域，学术界和工业界都对新的合成方法感兴趣。例如，桥接 1 的单步合成，具有潜在阻燃性能的 3-亚苯基双（二苯基次膦酸盐）被添加到该研究中。此外，该反应还用于合成新型有机磷酐。© 2012 Wiley Periodicals, Inc. 杂原子化学 23:216–222, 2012; 在 wileyonlinelibrary.com 上在线查看这篇文章。DOI 10.1002/hc.21006

  DOI：

  10.1002/hc.21006

文献信息

• Flame retarding agent, flame-retardant aqueous resin composition and flame-retardant urethane resin composition containing said flame-retarding agent, and use therefor
  申请人：Daihachi Chemical Industry Co., Ltd.

  公开号：US10000625B2

  公开（公告）日：2018-06-19

  The present invention relates to a flame-retarding agent comprising a phosphoramidate compound represented by Formula (I): wherein R1 and R2 are each independently C1-3 alkyl, R11 and R12 are each independently C1-3 alkylene, R13 is C1-6 alkylene, B1 is hydrogen or C1-6 alkyl, and A is hydrogen or an organic group represented by Formula (Ia): wherein R3 and R4 are each independently C1-3 alkyl, R14 and R15 are each independently C1-3 alkylene, and B2 is hydrogen or C1-6 alkyl, wherein when B1 is C1-6 alkyl, and A is hydrogen, B1 and R13-A, taken together with nitrogen to which they are attached, may form a non-aromatic nitrogen-containing heterocycle, and wherein when B1 is C1-6 alkyl, A is an organic group represented by Formula (Ia), and B2 is C1-6 alkyl, B1 and B2, taken together with nitrogen to which they are attached and with R13, may form a non-aromatic nitrogen-containing heterocycle.

  本发明涉及一种阻燃剂，它包含由式（I）表示的磷酰胺化合物： 其中 R1 和 R2 各自独立地为 C1-3 烷基，R11 和 R12 各自独立地为 C1-3 亚烷基，R13 为 C1-6 亚烷基，B1 为氢或 C1-6 烷基，A 为氢或由式 (Ia) 表示的有机基团： 其中 R3 和 R4 各自独立地为 C1-3 烷基，R14 和 R15 各自独立地为 C1-3 亚烷基，B2 为氢或 C1-6 烷基、 其中当 B1 是 C1-6 烷基，A 是氢时，B1 和 R13-A 与它们所连接的氮一起可形成非芳香族含氮杂环，以及 其中当 B1 为 C1-6 烷基，A 为式（Ia）所代表的有机基团，B2 为 C1-6 烷基时，B1 和 B2 与它们所连接的氮和 R13 一起可形成非芳香族含氮杂环。
• Aryl <i>H</i>-Phosphonates. 6. Synthetic Studies on the Preparation of Nucleoside <i>N</i>-Alkyl-<i>H</i>-phosphonamidates
  作者：Anna Sobkowska、Michał Sobkowski、Jacek Cieślak、Adam Kraszewski、Inger Kers、Jacek Stawiński

  DOI：10.1021/jo962224z

  日期：1997.7.1

  Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleoside H-phosphonates with pivaloyl chloride or chlorophosphates, followed by the addition of amines, notably diminished these side reactions. The most efficient and versatile route to nucleoside N-alkyl H-phosphonates was found to be aminolysis of the in situ-produced aryl nucleoside H-phosphonates with appropriate amines.
• TWI631131
  申请人：——

  公开号：——

  公开（公告）日：——
• Flame Retarding Agent, Flame-Retardant Aqueous Resin Composition And Flame-Retardant Urethane Resin Composition Containing Said Flame-Retarding Agent, And Use Therefor
  申请人：Daihachi Chemical Industry Co., Ltd.

  公开号：US20150197624A1

  公开（公告）日：2015-07-16

  The present invention relates to a flame-retarding agent comprising a phosphoramidate compound represented by Formula (I): wherein R 1 and R 2 are each independently C 1-3 alkyl, R 11 and R 12 are each independently C 1-3 alkylene, R 13 is C 1-6 alkylene, B 1 is hydrogen or C 1-6 alkyl, and A is hydrogen or an organic group represented by Formula (Ia): wherein R 3 and R 4 are each independently C 1-3 alkyl, R 14 and R 15 are each independently C 1-3 alkylene, and B 2 is hydrogen or C 1-6 alkyl, wherein when B 1 is C 1-6 alkyl, and A is hydrogen, B 1 and R 13 -A, taken together with nitrogen to which they are attached, may form a non-aromatic nitrogen-containing heterocycle, and wherein when B 1 is C 1-6 alkyl, A is an organic group represented by Formula (Ia), and B 2 is C 1-6 alkyl, B 1 and B 2 , taken together with nitrogen to which they are attached and with R 13 , may form a non-aromatic nitrogen-containing heterocycle.
• FLAME RETARDANT AND FLAME RETARDANT POLYURETHANE RESIN COMPOSITION
  申请人：DAIHACHI CHEMICAL INDUSTRY CO., LTD.

  公开号：US20160244582A1

  公开（公告）日：2016-08-25

  The present invention provides a polyurethane which has excellent flame retardance and various excellent performances. A phosphoramidate compound having a specific structure is used as a flame retardant for a polyurethane foam or a polyurethane elastomer. By mixing this flame retardant with a raw material of a polyurethane resin (polyol, polyisocyanate and various additives), a polyurethane reactive raw material composition is obtained. By reacting the polyisocyanate and active hydrogen-containing compounds such as polyol in the polyurethane reactive raw material composition, a curing reaction takes place and a polyurethane foam composition or polyurethane elastomer composition is obtained. The obtained polyurethane resin composition has excellent flame retardance and other excellent performances as the polyurethane foam or polyurethane elastomer.