2-(3-fluoro-4-hydroxyphenyl)-6-methoxy-1H-isoquinolin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂非酮类
• 英文名称: 2-(3-fluoro-4-hydroxyphenyl)-6-methoxy-1H-isoquinolin-8-ol
• 化学式: C₁₆H₁₄FNO₃
• 分子量: 287.28
• InChiKey: SNYQMAASVKBXTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ALDO-KETO REDUCTASE SUBFAMILY 1C3 (AKR1C3) INHIBITORS<br/>[FR] INHIBITEURS DE LA SOUS-FAMILLE 1C3 DE L'ALDO-CÉTO RÉDUCTASE (AKR1C3)
  申请人：GTX INC

  公开号：WO2014039820A1

  公开（公告）日：2014-03-13

  The present invention relates to a novel class of AKR1C3 inhibitors, to compositions containing them, to methods for their preparation, and to methods of use thereof. The AKR1C3 inhibitors may be useful in the treatment of, for example, prostate cancer, benign prostate hyperplasia (BPH), lung cancer, acne, seborrhea, hirsuitism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, uterine cancer, uterine fibroids, endometriosis, myeloma and leiomyoma.