(2S)-2,6-bis[bis[[1-[2-[2-[(2R,3S,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]hexanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: (2S)-2,6-bis[bis[[1-[2-[2-[(2R,3S,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]hexanoic acid
• 化学式: C₆₆H₁₁₀N₁₈O₃₀
• 分子量: 1635.7
• InChiKey: TUCZRQZDGQXVBE-BBZHTCAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -14.1
• 重原子数：
  114
• 可旋转键数：
  51
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  637
• 氢给体数：
  17
• 氢受体数：
  40

文献信息

• [EN] NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES<br/>[FR] NOUVEAUX CONJUGUÉS CONTENANT TÉTRAGALNAC ET PEPTIDE ET PROCÉDÉS POUR L'ADMINISTRATION D'OLIGONUCLÉOTIDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2013166155A1

  公开（公告）日：2013-11-07

  Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

  本文揭示了一种模块化组合物，包括1）寡核苷酸；2）一个或多个符合式(I)的四聚GalNAc配体，可以相同也可以不同；可选地，3）一个或多个连接剂，可以相同也可以不同；4）从表3中独立选择的一个或多个肽，可以相同也可以不同；以及可选地，5）一个或多个靶向配体、增溶剂、药代动力学增强剂、脂质和/或掩蔽剂。
• NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
  申请人：Sirna Therapeutics, Inc.

  公开号：US20150203843A1

  公开（公告）日：2015-07-23

  Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

  本发明公开了一种模块化组合物，包括：1）寡核苷酸；2）一种或多种四糖基N-乙酰半乳胺配体（公式（I）），可以相同或不同；可选地，3）一种或多种连接剂，可以相同或不同；以及可选地，4）一种或多种靶向配体、溶解剂、药代动力学增强剂、脂质和/或掩蔽剂。
• NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
  申请人：Sima Therapeutics, Inc.

  公开号：US20150246133A1

  公开（公告）日：2015-09-03

  Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

  本文披露了一种模块化组合物，包括：1）寡核苷酸；2）一个或多个四糖基N-乙酰半胱氨酸配体（I式），可以相同或不同；可选地，3）一个或多个连接剂，可以相同或不同；4）从表3中独立选择的一个或多个肽，可以相同或不同；以及可选的5）一个或多个靶向配体、溶解剂、药代动力学增强剂、脂质和/或伪装剂。
• SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
  申请人：Carr Brian Allen

  公开号：US20150299696A1

  公开（公告）日：2015-10-22

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

  本发明涉及化合物、组合物和方法，用于研究、诊断和治疗对基因表达和/或活性调节、和/或调节基因表达途径有反应的特征、疾病和病症。具体而言，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA）分子，能够介导或介导靶基因表达的RNA干扰（RNAi）。
• SHORT INTERFERING NUCLEIC ACID (SINA) COMPOSITIONS
  申请人：Sirna Therapeutics, Inc.

  公开号：EP3358013A1

  公开（公告）日：2018-08-08

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

  本发明涉及用于研究、诊断和治疗对基因表达和/或活性调节和/或基因表达途径调节有反应的性状、疾病和病症的化合物、组合物和方法。具体来说，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA）分子，它们能够介导或介导针对靶基因表达的 RNA 干扰（RNAi）。