13-Methyl-3,4,9,11-tetrazatricyclo[8.4.0.03,7]tetradeca-1(10),4,6,11,13-pentaen-8-one

分子结构分类

有机化合物 - 有机杂环化合物 - 吡啶二氮卓类

中文名称

——

中文别名

——

英文名称

13-Methyl-3,4,9,11-tetrazatricyclo[8.4.0.03,7]tetradeca-1(10),4,6,11,13-pentaen-8-one

英文别名

13-methyl-3,4,9,11-tetrazatricyclo[8.4.0.03,7]tetradeca-1(10),4,6,11,13-pentaen-8-one

CAS

——

化学式

C₁₁H₁₀N₄O

mdl

——

分子量

214.22

InChiKey

WCMDDPMLNBGSQS-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

0.7
重原子数：

16
可旋转键数：

0
环数：

3.0
sp3杂化的碳原子比例：

0.18
拓扑面积：

59.8
氢给体数：

1
氢受体数：

3

文献信息

[EN] NEW ANTIBACTERIAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS ANTIBACTÉRIENS

申请人：JANSSEN R & D IRELAND

公开号：WO2014023815A1

公开（公告）日：2014-02-13

The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.

本发明涉及一种可能抑制FabI酶活性的化合物（I）的新化合物，这些化合物在治疗细菌感染中很有用。还涉及包含这些化合物的药物组合物，以及制备这些化合物的化学过程。
NEW ANTIBACTERIAL COMPOUNDS

申请人：Janssen Sciences Ireland UC

公开号：EP2882738B1

公开（公告）日：2017-05-31
ANTIBACTERIAL COMPOUNDS

申请人：JANSSEN SCIENCES IRELAND UC

公开号：US20150210719A1

公开（公告）日：2015-07-30

The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
Antibacterial compounds

申请人：JANSSEN SCIENCES IRELAND UC

公开号：US20150225424A1

公开（公告）日：2015-08-13

The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
US9296760B2

申请人：——

公开号：US9296760B2

公开（公告）日：2016-03-29

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13-Methyl-3,4,9,11-tetrazatricyclo[8.4.0.03,7]tetradeca-1(10),4,6,11,13-pentaen-8-one

分子结构分类

计算性质

文献信息

同类化合物

相关结构分类

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