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    首页 分子通 1-[4-(1,2,4-Triazol-1-yl)cyclohexyl]thieno[2,3-d]imidazole

    1-[4-(1,2,4-Triazol-1-yl)cyclohexyl]thieno[2,3-d]imidazole

    分子结构分类

    有机化合物 - 有机杂环化合物 - 噻吩并咪唑类
    中文名称
    ——
    中文别名
    ——
    英文名称
    1-[4-(1,2,4-Triazol-1-yl)cyclohexyl]thieno[2,3-d]imidazole
    英文别名
    1-[4-(1,2,4-triazol-1-yl)cyclohexyl]thieno[2,3-d]imidazole
    1-[4-(1,2,4-Triazol-1-yl)cyclohexyl]thieno[2,3-d]imidazole化学式
    CAS
    ——
    化学式
    C13H15N5S
    mdl
    ——
    分子量
    273.36
    InChiKey
    YKLCKRATJKLCIN-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      2.4
    • 重原子数：
      19
    • 可旋转键数：
      2
    • 环数：
      4.0
    • sp3杂化的碳原子比例：
      0.46
    • 拓扑面积：
      76.8
    • 氢给体数：
      0
    • 氢受体数：
      4

    文献信息

    • [EN] TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS<br/>[FR] DÉRIVÉS DE THIOPHÈNE CONDENSÉS TRICYCLIQUES À TITRE D'INHIBITEURS DE JAK
      申请人：INCYTE CORP
      公开号：WO2014071031A1
      公开（公告）日：2014-05-08
      The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    查看更多

    同类化合物

    沙维拉唑 4H-吡咯并[1,2-a]噻吩并[3,2-D]咪唑 3H-噻吩并[2,3-d]咪唑-5-羧酸 3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮 2-(氯甲基)-1H-噻吩并[3,4-d]咪唑 1H-噻吩并[3,2-D]咪唑-2(3H)-酮 1H-噻吩并[2,3-d]咪唑,1-乙烯基-(9CI) 1H-噻吩并(3,4-d)咪唑,2-(((5-甲基-2-吡啶基)甲基)亚硫酰基)- 1-甲基-1H-噻吩并[2,3-D]咪唑基-2(3H)-酮 1-乙烯基-1H-噻吩并[2,3-d]咪唑-5-羧酸 1,3-二氢噻吩并[3,4-d]咪唑-2-硫酮 tert-butyl 4-[4-(2,3-dihydro-2-oxo-1-tert-butoxycarbonyl-1H-thieno[3,4-d]imidazol-4-yl)phenyl]-2,3-dihydro-2-oxo-1H-thieno[3,4-d]imidazole-1-carboxylate 2-(3-Bromo-4-methoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-[3-Methoxy-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethylsulfanyl]-1H-thieno[3,4-d]imidazole 2-(2-diethylaminobenzylmercapto)-1H-thieno[3,4-d]imidazole 2-(5-Bromo-4-methoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(5-Chloro-4-methoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(2-dimethylaminobenzylmercapto)-1H-thieno[3,4-d]imidazole 6-amino-1-vinylthieno[2,3-d]imidazole-5-carboxamide 1-Vinyl-1H-thieno[2,3-d]imidazole-5-carboxylic acid ethyl ester 2-(3-Chloro-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(5-Methoxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole (2S,4S)-tert-butyl 2-(5-(4-bromophenyl)-1H-thieno[2,3-d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate 1-methyl-2-methoxymethyl-thieno[2.3-d]imidazol-5-yl-carboxylic acid 2-(3-Fluoro-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-Benzyloxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-methoxy-2-picolylsulfinyl)-1H-thieno[3,4-d]imidazole 2-[(4-methoxypyridin-2-yl)methylsulfinyl]-1H-thieno[2,3-d]imidazole 4-(4-methoxyphenyl)-2-[(4-methoxypyridin-2-yl)methylsulfinyl]-1H-thieno[3,4-d]imidazole 2-(4-methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole methyl 2-[(4-methoxypyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole-4-carboxylate 2-[(4-methoxypyridin-2-yl)methylsulfinyl]-4-phenyl-1H-thieno[3,4-d]imidazole dimethyl 2-[(4-methoxypyridin-2-yl)methylsulfinyl]-1H-thieno[2,3-d]imidazole-5,6-dicarboxylate 2-[(4-methoxypyridin-2-yl)methylsulfanyl]-1H-thieno[2,3-d]imidazole methyl 2-[(4-methoxypyridin-2-yl)methylsulfinyl]-1H-thieno[3,4-d]imidazole-4-carboxylate 1-Ethoxycarbonyl-2-(4-methoxy-2-picolylsulfinyl)-1H-thieno[3,4-d]imidazole 1-ethoxycarbonyl-2-(4-methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole ethyl 2-methylthieno[2,3-d]imidazol-5-carboxylate 2-[(5-chloropyridin-2-yl)methylsulfinyl]-1H-thieno[3,4-d]imidazole 2-[(4-Thiazolyl)methylthio]thieno[3,4-d]imidazole 2-[[3-Methoxy-4-(2,2,3,3,4,4,4-heptafluorobutoxy)-2-pyridinyl]methylsulfinyl]-1H-thieno[3,4-d]imidazole 2-[(3-methoxypyridin-2-yl)methylsulfinyl]-1H-thieno[3,4-d]imidazole 2-[(3,4-dimethoxypyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole 2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-thieno[3,4-d]imidazole 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-4-(4-methoxyphenyl)-1H-thieno[3,4-d]imidazole 2-(4-methoxy-3,5-dimethyl-2-picolylsulfinyl)-1H-thieno[3,4-d]imidazole 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-4-phenyl-1H-thieno[3,4-d]imidazole 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole (3S,3'S,5S,5'S)-tert-butyl 5,5'-(5,5'-(buta-1,3-diyne-1,4-diyl)bis(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-thieno[2,3-d]imidazole-5,2-diyl))bis(3-methylpyrrolidine-1-carboxylate) (2S,4S)-tert-butyl 2-(5-ethynyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-thieno[2,3-d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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