1-N'-[(5Z)-5-(1-aminoethylidene)imidazol-4-yl]ethane-1,1-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 1-N'-[(5Z)-5-(1-aminoethylidene)imidazol-4-yl]ethane-1,1-diamine
• 化学式: C₇H₁₃N₅
• 分子量: 167.21
• InChiKey: OAWQLPFGPUFLFH-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  88.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] BIOREDUCIBLE POLY (B-AMINO ESTER)S FOR SIRNA DELIVERY<br/>[FR] POLY(ESTER B-AMINO) BIORÉDUCTIBLE POUR L'ADMINISTRATION D'ARNSI
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014066811A1

  公开（公告）日：2014-05-01

  Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.

  合成了可降解聚合物，可与核酸、蛋白质、疏水药物和其他小分子自组装形成颗粒，有效地输送到细胞、组织和/或生物体内，无论在体外还是体内。目前披露的聚合物表现出细胞类型特异性差异，能够促进内体逃逸以保护货物免受降解并增强输送到细胞质的能力和/或生物还原性，使触发的细胞内药物释放可调节以促进最佳输送到目标细胞类型。目前披露的材料可用于治疗各种疾病或病症，例如癌症、心血管疾病、传染病和眼科疾病。