tetraethyl hexane-1,6-diyl bisphosphate | 1265883-59-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: tetraethyl hexane-1,6-diyl bisphosphate
• 英文别名: tetraethyl 1,6-hexanediol diphosphoric acid ester；6-Diethoxyphosphoryloxyhexyl diethyl phosphate
• CAS: 1265883-59-7
• 化学式: C₁₄H₃₂O₈P₂
• 分子量: 390.351
• InChiKey: MUELRGCHJCGYFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,6-己二醇 、 氯磷酸二乙酯 在 吡啶 、 4-二甲氨基吡啶 作用下， 以70%的产率得到tetraethyl hexane-1,6-diyl bisphosphate
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel enolphosphate derivatives

  摘要：

  A new class of enolphosphates derivatives, the 1-alkenyldiphosphates, was designed and a rapid and efficient synthesis for these compounds was developed. These new molecules showed interesting in vitro antibacterial activities (MIC) against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative pathogens including Pseudomonas aeruginosa and Escherichia coli. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.06.006

文献信息

• Synthesis and antibacterial activity of novel enolphosphate derivatives
  作者：Claude Grison、Nicolas Barthes、Chantal Finance、Raphael E. Duval

  DOI：10.1016/j.bioorg.2010.06.006

  日期：2010.10

  A new class of enolphosphates derivatives, the 1-alkenyldiphosphates, was designed and a rapid and efficient synthesis for these compounds was developed. These new molecules showed interesting in vitro antibacterial activities (MIC) against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative pathogens including Pseudomonas aeruginosa and Escherichia coli. (C) 2010 Elsevier Inc. All rights reserved.