chloro-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]phosphinic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: chloro-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]phosphinic acid
• 化学式: C₆H₁₃ClNO₃P
• 分子量: 213.6
• InChiKey: VUEWMKBAYHDFIR-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF
  申请人：Sarepta Therapeutics, Inc.

  公开号：US20140330006A1

  公开（公告）日：2014-11-06

  Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了包含修改的亚单位间连接和/或修改的3'和/或5'-末端基团的功能修饰寡核苷酸类似物。所公开的化合物对于治疗需要抑制蛋白质表达或纠正异常mRNA剪接产物以产生有益治疗效果的疾病是有用的。
• PEPTIDE OLIGONUCLEOTIDE CONJUGATES
  申请人：SAREPTA THERAPEUTICS, INC.

  公开号：US20160237426A1

  公开（公告）日：2016-08-18

  Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了与载体肽共轭的寡核苷酸类似物。所公开的化合物对于治疗各种疾病是有用的，例如在抑制蛋白质表达或修正异常mRNA剪接产物产生有益的治疗效果的疾病中。
• Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
  申请人：Sarepta Therapeutics, Inc.

  公开号：US10202602B2

  公开（公告）日：2019-02-12

  Oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了包含修饰的亚基间连接和/或修饰的 3′和/或 5′末端基团的寡核苷酸类似物。所公开的化合物可用于治疗抑制蛋白质表达或校正异常 mRNA 剪接产物产生有益治疗效果的疾病。
• Functionally-modified oligonucleotides and subunits thereof
  申请人：Sarepta Therapeutics, Inc.

  公开号：US11208655B2

  公开（公告）日：2021-12-28

  Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  本研究提供了功能修饰的寡核苷酸类似物，这些类似物包含修饰的亚基间连接和/或修饰的 3′和/或 5′末端基团。所公开的化合物可用于治疗抑制蛋白质表达或校正异常 mRNA 剪接产物产生有益治疗效果的疾病。
• Peptide oligonucleotide conjugates
  申请人：Sarepta Therapeutics, Inc.

  公开号：US11225662B2

  公开（公告）日：2022-01-18

  Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了与载体肽连接的寡核苷酸类似物。所公开的化合物可用于治疗各种疾病，例如抑制蛋白质表达或校正异常 mRNA 剪接产物可产生有益治疗效果的疾病。