amino bis (diisopropylamino)phosphine oxide | 90670-66-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: amino bis (diisopropylamino)phosphine oxide
• 英文别名: Tetraisopropylphosphoramide；N-[amino-[di(propan-2-yl)amino]phosphoryl]-N-propan-2-ylpropan-2-amine
• CAS: 90670-66-9
• 化学式: C₁₂H₃₀N₃OP
• 分子量: 263.363
• InChiKey: KMDQMQGMZUCIDT-UHFFFAOYSA-N

物化性质

• 沸点：
  329.7±25.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Azidophosphan 在 甲醇 、 sulfur 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 19.0h， 生成 amino bis (diisopropylamino)phosphine oxide
  参考文献：
  名称：

  叠氮化磷的多功能光化学行为：α-磷氮烯的 Curtius 型重排和不同的命运

  摘要：

  叠氮双二异丙基氨基膦和氧化、硫和苯亚胺的同系物

  DOI：

  10.1021/ja00299a033

文献信息

• Versatile photochemical behavior of phosphorus azides: Curtius-type rearrangement and diverse fates of .alpha.-phosphorus nitrenes
  作者：Antoine Baceiredo、Guy Bertrand、Jean Pierre Majoral、Fatiha El Anba、George Manuel

  DOI：10.1021/ja00299a033

  日期：1985.6

  Comportement de l'azido bis-diisopropylamino phosphine et de ses homogues oxyde, sulfure et phenylimine

  叠氮双二异丙基氨基膦和氧化、硫和苯亚胺的同系物
• Assay for detecting, measuring and monitoring the activities and concentrations of proteins and methods of use thereof
  申请人：——

  公开号：US20020165620A1

  公开（公告）日：2002-11-07

  An assay for detecting, measuring, or monitoring the activity or concentration of at least two proteins that have similar or overlapping properties is disclosed. The assay comprises first determining the sensitivity coefficients of the substrates for each of the proteins in which the concentrations are to be determined. This method may be used for detecting, measuring, or monitoring the activity and concentration of AChE, BChE, or both in a test sample which test sample may be whole and unprocessed blood or tissue. Also disclosed are methods of using the assay to detect a subject's exposure to an agent which affects cholinesterase, determine the efficacy or progress of a treatment, determine the amount of protection provided against exposure to an agent which affects cholinesterase, or both, screen a subject for having a drug sensitivity or a particular disease, detect a change in red blood cell count of a subject, determine whether a candidate compound affects cholinesterase. Also disclosed are devices and kits for detecting, measuring, or monitoring the activities and concentrations of AChE, BChE, or both.

  本发明公开了一种用于检测、测量或监控至少两种具有相似或重叠特性的蛋白质的活性或浓度的化验方法。该检测方法包括首先确定底物对每种要确定浓度的蛋白质的灵敏系数。该方法可用于检测、测量或监控测试样本中 AChE、BChE 或两者的活性和浓度，测试样本可以是未经处理的全血或组织。还公开了使用该检测方法检测受试者是否接触了影响胆碱酯酶的制剂、确定治疗的疗效或进展、确定对接触影响胆碱酯酶的制剂或两者所提供的保护量、筛查受试者对药物的敏感性或特定疾病、检测受试者红细胞计数的变化、确定候选化合物是否影响胆碱酯酶。还公开了用于检测、测量或监控 AChE、BChE 或两者的活性和浓度的装置和试剂盒。
• Sicard, Ghislaine; Baceiredo, Antoine; Bertrand, Guy, Angewandte Chemie, 1984, vol. 96, # 6, p. 450 - 451
  作者：Sicard, Ghislaine、Baceiredo, Antoine、Bertrand, Guy、Majoral, Jean-Pierre

  DOI：——

  日期：——
• SICARD, GH.;BACEIREDO, A.;BERTRAND, G.;MAJORAL, J. -P., ANGEW. CHEM., 1984, 96, N 6, 450-451
  作者：SICARD, GH.、BACEIREDO, A.、BERTRAND, G.、MAJORAL, J. -P.

  DOI：——

  日期：——
• ASSAY FOR DETECTING, MEASURING AND MONITORING THE ACTIVITIES AND CONCENTRATIONS OF PROTEINS AND METHODS OF USE THEREOF
  申请人：United States Army Medical Research and Material Command

  公开号：EP1283902A1

  公开（公告）日：2003-02-19