4-amino-N'-[2-(methanesulfonamido)ethyl]-1,2,5-oxadiazole-3-carboximidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 4-amino-N'-[2-(methanesulfonamido)ethyl]-1,2,5-oxadiazole-3-carboximidamide
• 化学式: C₆H₁₂N₆O₃S
• 分子量: 248.27
• InChiKey: MWJQPKFLBHXWCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  158
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase
  申请人：Incyte Corporation

  公开号：US20140315962A1

  公开（公告）日：2014-10-23

  The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

  本发明涉及1,2,5-噁二唑衍生物及其组合物，它们是色胺酸2,3-双加氧酶的抑制剂，可用于治疗癌症和其他疾病，并涉及制备这种1,2,5-噁二唑衍生物的过程和中间体。
• 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
  申请人：Incyte Corporation

  公开号：US10034864B2

  公开（公告）日：2018-07-31

  The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

  本发明涉及 1,2,5-噁二唑衍生物及其组合物，它们是吲哚胺 2,3-二氧 化酶的抑制剂，可用于治疗癌症和其他疾病；本发明还涉及制造这种 1,2,5-噁二唑衍 生物的工艺和中间体。
• 1,2,5-Oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
  申请人：Incyte Corporation

  公开号：US10369137B2

  公开（公告）日：2019-08-06

  The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

  本发明涉及 1,2,5-噁二唑衍生物及其组合物，它们是吲哚胺 2,3-二氧 化酶的抑制剂，可用于治疗癌症和其他疾病；本发明还涉及制造这种 1,2,5-噁二唑衍 生物的工艺和中间体。
• US8796319B2
  申请人：——

  公开号：US8796319B2

  公开（公告）日：2014-08-05
• US8993605B2
  申请人：——

  公开号：US8993605B2

  公开（公告）日：2015-03-31