[2-(hydroxymethyl)morpholin-4-yl]-N,N-dimethylphosphonamidic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [2-(hydroxymethyl)morpholin-4-yl]-N,N-dimethylphosphonamidic acid
• 化学式: C₇H₁₇N₂O₄P
• 分子量: 224.19
• InChiKey: MAFBRQLHRYIKFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compositions of ascorbic acid and bone morphogenetic protein 4 (BMP-4) for cell growth and uses related thereo
  申请人：EMORY UNIVERSITY

  公开号：US10206955B2

  公开（公告）日：2019-02-19

  This disclosure relates to compositions comprising ascorbic acid and bone morphogenetic protein 4 (BMP-4) for growing cells and making tissues. In certain embodiments, this disclosure relates to methods of creating cardio-mimetic tissues (CMTs) by culturing the cells in the presence of ascorbic acid and bone morphogenetic protein 4 and optionally inserting into cells a muscle specific microRNA or related nucleobase polymer and under conditions such that a cardio-mimetic tissue is formed that is capable of spontaneously contracting.

  本公开涉及包含抗坏血酸和骨形态发生蛋白4（BMP-4）的组合物，用于生长细胞和制造组织。在某些实施方案中，本公开涉及通过在抗坏血酸和骨形态发生蛋白 4 的存在下培养细胞，并选择性地向细胞中插入肌肉特异性 microRNA 或相关核碱基聚合物，以及在形成能够自发收缩的仿心肌组织的条件下制造仿心肌组织（CMT）的方法。
• Compositions and methods for managing respiratory conditions
  申请人：Emory University

  公开号：US10738079B2

  公开（公告）日：2020-08-11

  This disclosure relates to compositions for use in managing respiratory distress and related disorders. In certain embodiments, the disclosure relates to methods of treating or preventing respiratory distress comprising administering an effective amount of a pharmaceutical composition comprising peptides or agents disclosed herein to a subject in need thereof. In certain embodiments, the peptides or agents decrease the concentration of claudin-5 in cells and tissues of the lungs.

  本公开涉及用于治疗呼吸窘迫和相关疾病的组合物。在某些实施方案中，本公开涉及治疗或预防呼吸窘迫的方法，包括向有需要的受试者施用有效量的药物组合物，该组合物包含本文公开的肽或制剂。在某些实施方案中，多肽或制剂可降低肺细胞和组织中Claudin-5的浓度。
• Devices and methods useful for detecting mechanical forces of ligand receptor interactions
  申请人：Emory University

  公开号：US10900069B2

  公开（公告）日：2021-01-26

  This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting mechanical forces between a ligand and receptor, where the ligand is immobilized on a surface using weaker forces. Ligand-receptor forces lead to dissociation of the ligand that can be detected and amplified. In certain embodiments, the disclosure relates to methods of detecting ligand and receptor interactions comprising linking a ligand to one of two binding partners, wherein the binding partners have attracting forces that are less than the forces between the ligand and a receptor of the ligand such that when the ligand binds the receptor, the binding partners will separate. Separation of the binding partners can be detected.

  本公开涉及检测分离配体和受体相互作用所需的机械力的方法。在某些实施方案中，本公开涉及检测配体与受体之间机械力的方法，其中配体利用较弱的力固定在表面上。配体与受体的作用力会导致配体解离，这种解离可以被检测和放大。在某些实施方案中，本公开涉及检测配体与受体相互作用的方法，包括将配体与两个结合伙伴中的一个连接起来，其中结合伙伴的吸引力小于配体与配体受体之间的作用力，这样当配体与受体结合时，结合伙伴就会分离。可以检测到结合配体的分离。
• Particles with RNA cleaving nucleobase polymers and uses for managing inflammatory disorders
  申请人：Emory University

  公开号：US10905710B2

  公开（公告）日：2021-02-02

  This disclosure relates to nucleobase polymers useful for degrading GATA-3 mRNA. In certain embodiments, this disclosure relates to nucleobase polymers and nanoparticles conjugated to nucleobase polymers disclosed herein. In certain embodiments, the nucleobase polymers or nanoparticles can be used in methods of managing disorders associated with excessive GATA-3 expression in inflammatory disorders and respiratory disorders such as asthma.

  本公开涉及可用于降解 GATA-3 mRNA 的核碱基聚合物。在某些实施方案中，本公开涉及核碱基聚合物和与本文公开的核碱基聚合物共轭的纳米颗粒。在某些实施方案中，核碱基聚合物或纳米颗粒可用于管理与炎症性疾病和呼吸系统疾病（如哮喘）中 GATA-3 过度表达相关的疾病的方法。
• Methods and compositions for managing vascular conditions
  申请人：Emory University

  公开号：US11149274B2

  公开（公告）日：2021-10-19

  This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and blocking oligonucleotide therapeutic compositions and uses related thereto.

  本公开涉及通过靶向 microRNA 治理血管疾病的方法和组合物。 在某些实施方案中，本公开涉及反义、RNA 干扰和阻断寡核苷酸治疗组合物及其相关用途。