[3-Phosphonooxy-2-[[3-phosphonooxy-2,2-bis(phosphonooxymethyl)propoxy]methyl]-2-(phosphonooxymethyl)propyl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [3-Phosphonooxy-2-[[3-phosphonooxy-2,2-bis(phosphonooxymethyl)propoxy]methyl]-2-(phosphonooxymethyl)propyl] dihydrogen phosphate
• 英文别名: [3-phosphonooxy-2-[[3-phosphonooxy-2,2-bis(phosphonooxymethyl)propoxy]methyl]-2-(phosphonooxymethyl)propyl] dihydrogen phosphate
• 化学式: C₁₀H₂₈O₂₅P₆
• 分子量: 734.16
• InChiKey: CMPKPVJSQMTJDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10.4
• 重原子数：
  41
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  410
• 氢给体数：
  12
• 氢受体数：
  25

文献信息

• US20140271825A1
  申请人：——

  公开号：US20140271825A1

  公开（公告）日：2014-09-18
• PHARMACEUTICAL FORMULATIONS OF CHELATING AGENTS AS A METAL REMOVAL TREATMENT SYSTEM
  申请人：ZONEONE PHARMA, INC.

  公开号：US20170128366A1

  公开（公告）日：2017-05-11

  The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.
• PHARMACEUTICAL FORMULATIONS OF AND METHODS TO PREPARE CHELATING AGENTS FOR EFFICIENT METAL REMOVAL TREATMENT SYSTEMS
  申请人：HAYES Mark E.

  公开号：US20170239182A1

  公开（公告）日：2017-08-24

  The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can also contain essential trace metals to compensate for the off target effect of removal of endogenous non-target trace metals by administration of the chelator. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.
• [EN] PHARMACEUTICAL FORMULATIONS OF CHELATING AGENTS AS A METAL REMOVAL TREATMENT SYSTEM<br/>[FR] FORMULATIONS PHARMACEUTIQUES D'AGENTS CHÉLATANTS SOUS FORME DE SYSTÈME DE TRAITEMENT D'ÉLIMINATION DE MÉTAL
  申请人：ZONEONE PHARMA INC

  公开号：WO2014153192A1

  公开（公告）日：2014-09-25

  The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.
• [EN] PHARMACEUTICAL FORMULATIONS OF AND METHODS TO PREPARE CHELATING AGENTS FOR EFFICIENT METAL REMOVAL TREATMENT SYSTEMS<br/>[FR] FORMULATIONS PHARMACEUTIQUES ET PROCÉDÉS DE PRÉPARATION D'AGENTS CHÉLATANTS POUR SYSTÈMES EFFICACES DE TRAITEMENT D'ÉLIMINATION DES MÉTAUX
  申请人：ZONEONE PHARMA INC

  公开号：WO2016025559A1

  公开（公告）日：2016-02-18

  The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can also contain essential trace metals to compensate for the off target effect of removal of endogenous non-target trace metals by administration of the chelator. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.