phosphoric acid bis-(2-isopropyl-phenyl ester) | 125316-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: phosphoric acid bis-(2-isopropyl-phenyl ester)
• 英文别名: Phosphorsaeure-bis-(2-isopropyl-phenylester)；Bis-(2-isopropyl-phenyl)-phosphat；Bis(2-propan-2-ylphenyl) hydrogen phosphate
• CAS: 125316-97-4
• 化学式: C₁₈H₂₃O₄P
• 分子量: 334.352
• InChiKey: BEAFHPLLBXXUHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三(异丙基苯基)磷酸酯 在 氢氧化钾 作用下， 生成 phosphoric acid bis-(2-isopropyl-phenyl ester)
  参考文献：
  名称：

  The Effects of Growth Hormone Replacement Therapy on Bone Metabolism in Adult-Onset Growth Hormone Deficiency: A 2-Year Open Randomized Controlled Multicenter Trial

  摘要：

  成人生长激素缺乏症（GHD）患者表现出骨量显著减少和骨折率增加。生长激素（GH）替代治疗能够增加骨代谢率。关于骨矿含量（BMC）和骨密度（BMD）的长期数据主要来自于开放式的非对照试验，涉及患者人数有限。为了确定尽管骨代谢率增加但长期GH治疗是否对骨骼有益，研究将100名（59名男性和41名女性），年龄介于25至65岁（平均年龄49.7岁）且具有成年起病GHD的患者随机分配至GH治疗组（40名男性和28名女性；平均剂量为0.18 IU/kg每周）或未治疗对照组（19名男性和13名女性），持续24个月。尽管GH治疗组男性和女性患者的骨代谢参数（骨钙素[OC]，I型前胶原羧端前肽[PICP]，和吡啶醇[PYD]）与对照组相比均有类似的增加，但通过双能X射线吸收测定法评估的BMC和BMD的效果在性别上有所差异。与对照组的变化相比，男性GH治疗组患者的脊柱BMC和BMD及总髋BMD显著增加，超远端桡骨BMD则有所减少（24个月的平均±标准误变化：+6.8 ± 1.1%，p = 0.009；+5.1 ± 0.8%，p = 0.005；+3.5 ± 0.7%，p = 0.02；和−2.6 ± 0.8%，p = 0.008）。在女性患者中未观察到显著的治疗效果。尽管GH治疗导致总重塑空间增加，成年起病GHD的长期GH治疗对骨平衡有积极影响，在两年内能够维持女性的骨量，甚至在男性中增加骨量。

  DOI：

  10.1359/jbmr.2002.17.6.1081

文献信息

• Flame-retardant resin composition
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0767204A2

  公开（公告）日：1997-04-09

  The present invention provides a flame-retardant resin composition in which a total of 3 to 30 parts by weight of (B) a condensed phosphate ester flame retardant described by general formula (1) hereinbelow and (C) a monophosphate ester flame retardant described by general formula (2) hereinbelow is blended with 100 parts by weight of (A) polyphenylene ether resin or polycarbonate resin, components (B) and (C) being used in the range of (B)/B)+ (C)} = 0.5-0.9.    (where R1, R2, R3 and R4 denote a phenyl group, a lower alkyl group with 1 to 6 carbon atoms, or a hydrogen atom with the proviso that R1, R2, R3 and R4 are not all hydrogen atoms); X1 and X2 represent oxygen or sulphur atoms; Y denotes a phenyl group, lower alkyl group with 1 to 6 carbon atoms, or a sulfonyl group; R5, R6, and R7 denote a phenyl group, cresyl group, xylenyl group, or trimethylphenyl group lower alkyl group with 1 to 6 carbon atoms or a hydrogen atom (with the proviso that R5, R6 and R7 are not all hydrogen atoms) and n is an integer greater than or equal to 1 denoting degree of polymerization).

  本发明提供了一种阻燃树脂组合物，其中将总重量为 3 至 30 份（按重量计）的(B) 下文通式(1)所述的缩合磷酸酯阻燃剂和(C) 下文通式(2)所述的单磷酸酯阻燃剂与 100 份（按重量计）的(A)聚苯醚树脂或聚碳酸酯树脂混合，组分(B)和(C)的使用范围为(B)/B)+ (C)} = 0.5-0.9. (其中 R1、R2、R3 和 R4 表示苯基、1-6 个碳原子的低级烷基或氢原子，但 R1、R2、R3 和 R4 并不全是氢原子）；X1 和 X2 表示氧原子或硫原子；Y 表示苯基、1-6 个碳原子的低级烷基或磺酰基；R5、R6 和 R7 表示苯基、甲酚基、二甲苯基或具有 1 至 6 个碳原子的三甲基苯基低级烷基或氢原子（但 R5、R6 和 R7 不全是氢原子），n 是大于或等于 1 的整数，表示聚合度）。
• Aromatic polymer, method for producing the same and uses thereof
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1348716A1

  公开（公告）日：2003-10-01

  There is provided a polymer electrolyte which shows excellent characteristics as proton conductive membrane of fuel cells and the like. This polymer electrolyte contains an aromatic polymer which is characterized by having a super strong acid group in a side chain.

  本发明提供了一种聚合物电解质，它作为燃料电池等的质子传导膜具有优异的特性。这种聚合物电解质含有一种芳香族聚合物，其特点是侧链中含有一个超强酸基。
• Porous cement composition for propping fractures open
  申请人：HALLIBURTON ENERGY SERVICES, INC.

  公开号：US10011764B2

  公开（公告）日：2018-07-03

  A method of fracturing a subterranean formation comprising: introducing a fracturing fluid into the subterranean formation to create or enhance one or more fractures in the subterranean formation; introducing a cement composition into the one or more fractures, wherein the cement composition comprises: (A) cement; (B) water; and (C) an additive; and allowing the cement composition to set, wherein the additive creates a plurality of pores within the set cement.

  一种压裂地下地层的方法，包括：将压裂液引入地下地层，以在地下地层中形成或增强一个或多个裂缝；将水泥成分引入一个或多个裂缝，其中水泥成分包括：(A) 水泥；(B) 水；和 (C) 添加剂；以及使水泥成分凝固，其中添加剂在凝固的水泥中形成多个孔隙。
• Self-healing coatings for oil and gas applications
  申请人：Chilukuri Anusha

  公开号：US10316413B2

  公开（公告）日：2019-06-11

  A coated article comprises a substrate and a self-healing coating disposed on a surface of the substrate, the self-healing coating comprising a metallic matrix; and a plurality of micro- or nano-sized particles dispersed in the metallic matrix; the micro- or nano-sized particles comprising an active agent disposed in a carrier comprising a micro- or nano-sized metallic container, a layered structure, a porous structure, or a combination comprising at least one of the foregoing.

  一种涂层制品包括基底和设置在基底表面的自愈合涂层，自愈合涂层包括金属基质；以及分散在金属基质中的多个微米级或纳米级颗粒；微米级或纳米级颗粒包括设置在载体中的活性剂，载体包括微米级或纳米级金属容器、分层结构、多孔结构或包括上述至少一种结构的组合。
• Flame retardant, additive compositions, and flame retardant polyurethanes
  申请人：Hussain Saadat

  公开号：US20050113495A1

  公开（公告）日：2005-05-26

  Provided are new flame retardants and liquid flame retardant additive compositions of low viscosity for use in flexible polyurethane foams. The new flame retardants are the reaction product of at least one brominated aromatic diester diol with at least one alcohol-reactive agent. Preferred liquid flame retardant additive compositions are capable of minimizing visible scorching of the foam during its production. Flexible flame retardant polyurethane foams and methods for their production are also provided. The flame retardant additive compositions are formed at least from a) at least one reaction product of a brominated aromatic diester diol and an alcohol-reactive agent; b) at least one hindered amine antioxidant; and c) at least one phenolic antioxidant in which the phenolic ring is substituted by an alkanoic acid alkyl ester group in which alkanoic acid moiety has in the range of 2 to about 4 carbon atoms and the alkyl group has in the range of about 6 to about 16 carbon atoms.

  本文提供了用于软质聚氨酯泡沫的新型阻燃剂和低粘度液体阻燃添加剂组合物。新型阻燃剂是至少一种溴化芳香族二酯二醇与至少一种醇反应剂的反应产物。优选的液态阻燃添加剂组合物能够在泡沫生产过程中最大限度地减少可见的焦烧现象。此外，还提供了柔性阻燃聚氨酯泡沫及其生产方法。阻燃添加剂组合物至少由以下物质形成：a) 至少一种溴化芳香族二酯二元醇与醇反应剂的反应产物；b) 至少一种受阻胺抗氧化剂；c) 至少一种酚类抗氧化剂，其中酚环被烷酸烷基酯基团取代，烷酸分子的碳原子数在 2 至约 4 之间，烷基的碳原子数在约 6 至约 16 之间。