Palmitoyl-propandiol-(1,3)-phosphoryl-ethanolamin | 3947-63-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Palmitoyl-propandiol-(1,3)-phosphoryl-ethanolamin
• 英文别名: 3-[[(2-Aminoethoxy)hydroxyphosphinyl]oxy]propyl hexadecanoate；3-[2-aminoethoxy(hydroxy)phosphoryl]oxypropyl hexadecanoate
• CAS: 3947-63-5
• 化学式: C₂₁H₄₄NO₆P
• 分子量: 437.557
• InChiKey: DCXHMUNTKZYFLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Pegylated Liposomes and Methods of Use
  申请人：Infectious Disease Research Institute

  公开号：US20200138715A1

  公开（公告）日：2020-05-07

  Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210108198A1

  公开（公告）日：2021-04-15

  The present application relates to extracting a plurality of compounds from a traditional Chinese medicine, or synthesizing a compound capable of promoting nucleic acid delivery, and utilizing the extracted compound, or a plurality of combinations to promote absorption and entry of a nucleic acid such as sRNA into a target cell, and to facilitate the entry of a nucleic acid into a target site in a subject in need thereof.
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICALSCIENCES

  公开号：US20210100905A1

  公开（公告）日：2021-04-08

  The present application relates to extracting a plurality of compounds from a traditional Chinese medicine, or synthesizing a compound capable of promoting nucleic acid delivery, and utilizing the extracted compound, or a plurality of combinations to promote absorption and entry of a nucleic acid such as sRNA into a target cell, and to facilitate the entry of a nucleic acid into a target site in a subject in need thereof
• EXTRACTION OF PLANT SOURCE "MEDICINAL SOUP" AND MANUAL PREPARATION OF "HERBAL MEDICINE" AND RELATED PRODUCTS
  申请人：INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20210113641A1

  公开（公告）日：2021-04-22

  Provided is a method for preparing bencaosome comprising the steps of: mixing one or more lipid components with any one or more of the following: nucleic acid, compound and mancromolecules, and treating the obtained mixture by heating. Also provided is a method for extracting decoctosome from plants comprising the steps of: preparing an extract of the plant with a solvent; performing differential centrifugation to the extract; resuspending the precipitates with an aqueous solution to provide the decoctosome.
• PEGYLATED LIPOSOMES AND METHODS OF USE
  申请人：Infectious Disease Research Institute

  公开号：US20220160632A1

  公开（公告）日：2022-05-26

  Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.