3,5-dimethyl-6-ethylisoxazolo<4,5-b>pyridine-4-oxide | 144265-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异恶唑并吡啶类
• 英文名称: 3,5-dimethyl-6-ethylisoxazolo<4,5-b>pyridine-4-oxide
• 英文别名: 6-Ethyl-3,5-dimethyl-4-oxido-[1,2]oxazolo[4,5-b]pyridin-4-ium
• CAS: 144265-73-6
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: GOHIAOAFPXACGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-dimethyl-6-ethylisoxazolo<4,5-b>pyridine-4-oxide 在 三氯化磷 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以96%的产率得到3,5-dimethyl-6-ethylisoxazolo<4,5-b>pyridine
  参考文献：
  名称：

  A New One Step Synthetic Approach to the Isoxazolo[4,5-b]Pyridine System

  摘要：

  A convenient direct entry to the title ring system by condensation-cyclization processes of 3,5-dimethyl-4-nitroisoxazole (1) with the enamines 2 and 8 is reported; some reactions of the resulting N-oxides 5 and 10 are also described.

  DOI：

  10.1080/00397919208019090
• 作为产物：
  描述：

  4-(1-ethyl-propenyl)-morpholine 、 3,5-二甲基-4-硝基异噁唑 以 乙醇 为溶剂， 反应 24.0h， 以83%的产率得到3,5-dimethyl-6-ethylisoxazolo<4,5-b>pyridine-4-oxide
  参考文献：
  名称：

  A New One Step Synthetic Approach to the Isoxazolo[4,5-b]Pyridine System

  摘要：

  A convenient direct entry to the title ring system by condensation-cyclization processes of 3,5-dimethyl-4-nitroisoxazole (1) with the enamines 2 and 8 is reported; some reactions of the resulting N-oxides 5 and 10 are also described.

  DOI：

  10.1080/00397919208019090

文献信息

• Chary, T. Jagan Mohana; Murthy, A. Krishna; Rajanarendar, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2003, vol. 42, # 7, p. 1742 - 1745
  作者：Chary, T. Jagan Mohana、Murthy, A. Krishna、Rajanarendar

  DOI：——

  日期：——
• A New One Step Synthetic Approach to the Isoxazolo[4,5-<i>b</i>]Pyridine System
  作者：Rodolfo Nesi、Donatella Giomi、Stefania Turchi、Piero Tedeschi、Fabio Ponticelli

  DOI：10.1080/00397919208019090

  日期：1992.8

  A convenient direct entry to the title ring system by condensation-cyclization processes of 3,5-dimethyl-4-nitroisoxazole (1) with the enamines 2 and 8 is reported; some reactions of the resulting N-oxides 5 and 10 are also described.