Tetrahydro-2-(N-(2-chloroethyl)-N-ethylamino)-2H-1,3,2-oxazaphosphorine 2-oxide | 50650-73-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Tetrahydro-2-(N-(2-chloroethyl)-N-ethylamino)-2H-1,3,2-oxazaphosphorine 2-oxide
• 英文别名: N-(2-chloroethyl)-N-ethyl-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
• CAS: 50650-73-2
• 化学式: C₇H₁₆ClN₂O₂P
• 分子量: 226.64
• InChiKey: IDIGPIZVCYSCSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME
  申请人：Alonso Robert

  公开号：US20090247645A1

  公开（公告）日：2009-10-01

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: an alkylating agent such as, for example, a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• Stabilized Compositions Of Alkylating Agents And Methods Of Using Same
  申请人：Actelion Pharmaceuticals, Ltd.

  公开号：US20140142193A1

  公开（公告）日：2014-05-22

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: an alkylating agent such as, for example, a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• US8501817B2
  申请人：——

  公开号：US8501817B2

  公开（公告）日：2013-08-06