2,5-dimethyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one | 103807-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 2,5-dimethyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one
• 英文别名: 2,5-dimethyl-6-pyridin-4-yl-4H-1,4-thiazin-3-one
• CAS: 103807-33-6
• 化学式: C₁₁H₁₂N₂OS
• 分子量: 220.295
• InChiKey: BASQBTAAMSCNOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-dimethyl-6-[1-(2,2,2-trichloroethoxycarbonyl)-1,4-dihydro-4-pyridinyl]-2H-1,4-thiazin-3(4H)-one 在 sulfur 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以52%的产率得到2,5-dimethyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one
  参考文献：
  名称：

  Studies on bi-heterocyclic compounds. I. 6-Substituted dihydro-1,4-thiazinones.

  摘要：

  5-甲基-2H-1,4-噻嗪-3(4H)-酮(4)与各种N-酰基吡啶盐(7a-g)反应得到(N-酰基二氢吡啶基)噻嗪酮(5a-g)，将其氧化得到一类新的吡啶基噻嗪酮(6a-g)。这些反应被应用于其他含氮芳基噻嗪酮的合成。其中一些含氮芳基噻嗪酮，特别是6-(4-吡啶基)噻嗪酮(6a, 14a和14b)，显示出了对豚鼠左心房有正性肌力作用和较小的变时效应。

  DOI：

  10.1248/cpb.35.2243

文献信息

• 1,4-thiazine derivative, and cardiotonic agent comprising it as
  申请人：Zenyaku Kogyo Kabushiki Kaisha

  公开号：US04800201A1

  公开（公告）日：1989-01-24

  A novel 1,4-thiazine derivative represented by the formula I, a pharmaceutically acceptable acid addition salt thereof, a process for preparation thereof and a cardiotonic agent comprising it as an effective component; ##STR1## wherein R.sub.1 and R.sub.2 represent respectively hydrogen atom, lower alkyl group, lower alkoxy group, amino group, lower alkyl-amino group, aryl-amino group, hydroxy group, aryl group or 5- or 6-membered heterocyclic residue; R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group; and R.sub.5 represents N-containing heterocyclic residue and is not pyridinyl group when R.sub.1 and R.sub.2 represent hydrogen atom and R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group.

  一种由式I代表的新型1,4-噻嗪衍生物，其药学上可接受的酸盐，其制备方法以及作为有效成分的强心药剂；其中R.sub.1和R.sub.2分别代表氢原子，较低的烷基基团，较低的烷氧基团，氨基，较低的烷基氨基团，芳基氨基团，羟基，芳基或5-或6-成员杂环残基；R.sub.3和R.sub.4代表氢原子或较低的烷基基团；R.sub.5代表含氮杂环残基，当R.sub.1和R.sub.2代表氢原子且R.sub.3和R.sub.4代表氢原子或较低的烷基基团时，R.sub.5不代表吡啶基。
• 1,4-THIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND CARDIOTONICS CONTAINING THE SAME
  申请人：ZENYAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0233287A1

  公开（公告）日：1987-08-26

  Novel 1,4-thiazine derivatives represented by general formula (I) wherein R1 and R2 each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, an amino group, a lower alkylamino group, an arylamino group, a hydroxy group, an aryl group, a 5- or 6-membered heterocyclic ring residue, R3 and R4 each represents a hydrogen atom or a lower alkyl group, R5 represents a nitrogen-containing ring residue (provided that, when R, and R2 represent a hydrogen atom and R3 and R4 each represents a hydrogen atom or a lower alkyl group, R5 does not represent a pyridinyl group) and pharmacologically acceptable acid addition salts thereof, process for their preparation, and cardiotonics containing them as effective ingredients.

  通式(I)代表的新型1，4-噻嗪衍生物 其中R1和R2各自代表氢原子、低级烷基、低级烷氧基、氨基、低级烷基氨基、芳基氨基、羟基、芳基、5或6元杂环残基，R3和R4各自代表氢原子或低级烷基、R5 代表含氮环残基（条件是，当 R 和 R2 代表氢原子，R3 和 R4 各自代表氢原子或低级烷基时，R5 不代表吡啶基）及其药理学上可接受的酸加成盐、其制备工艺和含有它们作为有效成分的强心剂。
• TAKASEH, MUNEHAKI;JOSIOKA, KUNITOMO;YAMADZAKI, XIROSUKEH
  作者：TAKASEH, MUNEHAKI、JOSIOKA, KUNITOMO、YAMADZAKI, XIROSUKEH

  DOI：——

  日期：——
• YAMAZAKI HIROAKI; HARADA HIDENORI; MATSUZAKI KENICHI; YOSHIOKA KIMITOMO; +, CHEM. AND PHARM. BULL., 35,(1987) N 6, 2243-2253
  作者：YAMAZAKI HIROAKI、 HARADA HIDENORI、 MATSUZAKI KENICHI、 YOSHIOKA KIMITOMO、 +

  DOI：——

  日期：——
• JPS61225174A
  申请人：——

  公开号：JPS61225174A

  公开（公告）日：1986-10-06