4-Aminophenyl phosphate disodium

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 4-Aminophenyl phosphate disodium
• 英文别名: disodium;(4-aminophenyl) phosphate
• 化学式: C6H6NNa2O4P
• 分子量: 233.07
• InChiKey: LQHGVLDZRKLMCR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.52
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-Aminophenyl phosphate disodium 以8%的产率得到
  参考文献：
  名称：

  FOULDS, NICOLA C.;WILSHERE, JANE M.;GREEN, MONIKA J., ANAL. CHIM. ACTA., 229,(1990) N, C. 57-62

  摘要：

  DOI：

文献信息

• Heterocyclic angiogenesis inhibitors
  申请人：——

  公开号：US20020128232A1

  公开（公告）日：2002-09-12

  The present invention relates to novel angiogenic-inhibitory compounds of formula (I) 1 and pharmaceutically acceptable salts thereof, wherein: Y is a direct bond or a linker group selected from a group of CH 2 , NH, NR 1 , S, SO, SO 2 , or O; Z is CO, CS, SO, SO 2 , or C═NH; R 1 is H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, acyl, alkoxyacyl, aryloxyacyl, or aminoacyl groups; R 2 is O, S, or NH; A is one to three cycloalkyl or aryl ring groups, in which any of these ring groups may be connected with other ring through a single bond or fused with at least one other ring, and these ring groups are optionally substituted at one or more positions with alkyl, alkoxy, aryl, aryloxy, arylalkyl, arylalkyloxy, hydroxyl, halogen, trihalomethyl, S(O)R, SO 2 NRR′, SO 3 R, SR, B(OR) 2 , PR 3 , P(O)(OR) 2 , OP(O)(OR) 2 , NO 2 , NRR′, OR, CN, C(O)R, NHC(O)R, (CH 2 ) n CO 2 R, or CONRR′, wherein R and R′ are each independently selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, arylalkyl, and arylalkyloxy and n is 0-11; and B is alkyl, arylalkyl, or one to three cycloalkyl or aryl ring groups, in which any of ring groups may be connected with other ring through a single bond or fused with at least one other ring; and these alkyl, arylalkyl or ring groups are optionally substituted at one or more positions with alkyl, alkoxy, aryl, aryloxy, arylalkyl, arylalkyloxy, hydroxyl, halogen, trihalomethyl, S(O)R, SO 2 NRR′, SO 3 R, SR, B(OR) 2 , PR 3 , P(O)(OR) 2 , OP(O)(OR) 2 , NO 2 , NRR′, OR, CN, C(O)R, NHC(O)R, (CH 2 ) n CO 2 R, or CONRR′, wherein R and R′ are each independently selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, arylalkyl, and arylalkyloxy and n is 0-11, pharmaceutical composition comprising them and their use.

  本发明涉及公式(I)1的新型抑制血管生成的化合物及其药学上可接受的盐，其中：Y是直接键或从CH2、NH、NR1、S、SO、SO2或O组成的链联基；Z是CO、CS、SO、SO2或C═NH；R1是H、烷基、烯基、炔基、环烷基、芳基、芳基烷基、酰基、烷氧基酰基、芳氧基酰基或氨基酰基；R2是O、S或NH；A是一个至三个环烷基或芳基环，其中这些环中的任何一个可以通过单键连接到其他环或与至少一个其他环融合，这些环在一个或多个位置可选择地被烷基、烷氧基、芳基、芳氧基、芳基烷基、芳基烷氧基、羟基、卤素、三卤甲基、S(O)R、SO2NRR′、SO3R、SR、B(OR)2、PR3、P(O)(OR)2、OP(O)(OR)2、NO2、NRR′、OR、CN、C(O)R、NHC(O)R、(CH2)nCO2R或CONRR′取代，其中R和R′各自独立地选择自H、烷基、烷氧基、芳基、芳氧基、芳基烷基和芳基烷氧基组成的群，n为0-11；B是烷基、芳基烷基或一个至三个环烷基或芳基环，其中任何环群可以通过单键连接到其他环或与至少一个其他环融合；这些烷基、芳基烷基或环群在一个或多个位置可选择地被烷基、烷氧基、芳基、芳氧基、芳基烷基、芳基烷氧基、羟基、卤素、三卤甲基、S(O)R、SO2NRR′、SO3R、SR、B(OR)2、PR3、P(O)(OR)2、OP(O)(OR)2、NO2、NRR′、OR、CN、C(O)R、NHC(O)R、(CH2)nCO2R或CONRR′取代，其中R和R′各自独立地选择自H、烷基、烷氧基、芳基、芳氧基、芳基烷基和芳基烷氧基组成的群，n为0-11，包括它们的药物组成和它们的用途。
• WEATHER-RESISTANT DYE AND THE USE THEREOF
  申请人：Ninestar Management Co., Ltd.

  公开号：EP2298839A1

  公开（公告）日：2011-03-23

  The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.

  本发明涉及一种耐候性染料及其用途，其分子中不仅含有发色母体D，还含有通过非共轭碳链L与染料母体D连接构成D-L-Q染料分子的受电子基团Q；受电子基团Q的HOMO能级低于染料发色母体D的HOMO能级。该染料具有耐晒和抗臭氧性能，可用作墨水、涂料、油漆、激光打印墨粉、记号笔、纸张、织物、玻璃、陶瓷或聚合物的着色剂。
• Methods for detecting organisms and enzymatic reactions using raman spectroscopy and aromatic compounds comprising phosphate
  申请人：SWORD DIAGNOSTICS, INC.

  公开号：US10155973B2

  公开（公告）日：2018-12-18

  The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics.

  本公开提供了快速灵敏地检测样品中生物和分子的系统。产生拉曼活性产物的反应物与拉曼光散射结合使用。此类化合物可包括磷酸盐，以便检测磷酸酶。本公开内容还可用于测量酶动力学。
• MITOMYCIN DERIVATIVES HAVING REDUCED BONE MARROW TOXICITY, PROCESSES FOR THEIR PREPARATION, AND THE USES THEREOF
  申请人：GEORGETOWN UNIVERSITY

  公开号：EP0533692A1

  公开（公告）日：1993-03-31
• PARACETAMOL PHOSPHATE FOR IMMUNOASSAYS
  申请人：CAMBRIDGE LIFE SCIENCES PLC

  公开号：EP0759171A1

  公开（公告）日：1997-02-26