4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-1-(1-methylazetidin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡唑类
• 英文名称: 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-1-(1-methylazetidin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
• 英文别名: 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-1-(1-methylazetidin-3-yl)-4,5-dihydropyrrolo-[3,4-c]pyrazol-6(1H)-one；4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxopyridin-3-yl)-3-methyl-1-(1-methylazetidin-3-yl)-4H-pyrrolo[3,4-c]pyrazol-6-one
• 化学式: C₂₃H₂₄ClN₅O₂
• 分子量: 437.929
• InChiKey: RWLWADJBUXMBKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  61.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(azetidin-3-yl)-4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one 、 methanol-dichloromethane 生成 4-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-methyl-1-(1-methylazetidin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
  参考文献：
  名称：

  Pyrazolopyrrolidine derivatives and their use in the treatment of disease

  摘要：

  本发明提供了式（I）的化合物或其药学上可接受的盐；制造本发明化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合和制药组合物。

  公开号：

  US08975417B2

文献信息

• Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease
  申请人：BLANK Jutta

  公开号：US20140349990A1

  公开（公告）日：2014-11-27

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物的公式(I)或其药用盐；制备本发明化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合和制药组合物。
• PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：BLANK Jutta

  公开号：US20160095843A1

  公开（公告）日：2016-04-07

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了式（I）的化合物或其药学上可接受的盐，制备该发明化合物的方法以及其治疗用途。本发明还提供了一种药理活性剂的组合和一种药物组合物。
• AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS
  申请人：GENENTECH, INC.

  公开号：EP2922851B1

  公开（公告）日：2017-07-26
• US8975417B2
  申请人：——

  公开号：US8975417B2

  公开（公告）日：2015-03-10
• Pyrazolopyrrolidine derivatives and their use in the treatment of disease
  申请人：Bordas Vincent

  公开号：US08975417B2

  公开（公告）日：2015-03-10

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了式（I）的化合物或其药学上可接受的盐；制造本发明化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合和制药组合物。